Role of genetics in infection-associated arthritis

Benham, Helen, Robinson, Philip C., Baillet, Athan C., Rehaume, Linda M. and Thomas, Ranjeny (2015) Role of genetics in infection-associated arthritis. Best Practice and Research: Clinical Rheumatology, 29 2: 213-225. doi:10.1016/j.berh.2015.02.002

Author Benham, Helen
Robinson, Philip C.
Baillet, Athan C.
Rehaume, Linda M.
Thomas, Ranjeny
Title Role of genetics in infection-associated arthritis
Journal name Best Practice and Research: Clinical Rheumatology   Check publisher's open access policy
ISSN 1532-1770
Publication date 2015-01-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.berh.2015.02.002
Open Access Status Not yet assessed
Volume 29
Issue 2
Start page 213
End page 225
Total pages 13
Place of publication Kidlington, United Kingdom
Publisher Bailliere Tindall
Language eng
Subject 2745 Rheumatology
Abstract Genetic discoveries in arthritis and their associated biological pathways spanning the innate and adaptive immune system demonstrate the strong association between susceptibility to arthritis and control of exogenous organisms. The canonical theory of the aetiology of immune-mediated arthritis and other immune-mediated diseases is that the introduction of exogenous antigenic stimuli to a genetically susceptible host sets up the environment for an abnormal immune response manifesting as disease. A disruption in host-microbe homeostasis driven by disease-associated genetic variants could ultimately provide the source of exogenous antigen triggering disease development. We discuss genetic variants impacting the innate and adaptive arms of the immune system and their relationship to microbial control and arthritic disease. We go on to consider the evidence for a relationship between HLA-B27, infection and arthritis, and then emerging evidence for an interaction between microbiota and rheumatoid arthritis.
Keyword Spondyloarthropathy
Rheumatoid arthritis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2016 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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