Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics

Cocchi, Luca, Sale, Martin V., Lord, Anton, Zalesky, Andrew, Breakspear, Michael and Mattingley, Jason B. (2015) Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics. Journal of Neurophysiology, 113 9: 3375-3385. doi:10.1152/jn.00850.2014


Author Cocchi, Luca
Sale, Martin V.
Lord, Anton
Zalesky, Andrew
Breakspear, Michael
Mattingley, Jason B.
Title Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics
Journal name Journal of Neurophysiology   Check publisher's open access policy
ISSN 0022-3077
1522-1598
Publication date 2015-02-25
Year available 2015
Sub-type Article (original research)
DOI 10.1152/jn.00850.2014
Open Access Status DOI
Volume 113
Issue 9
Start page 3375
End page 3385
Total pages 11
Place of publication Bethesda, MD United States
Publisher American Physiological Society
Collection year 2016
Language eng
Formatted abstract
Normal brain function depends on a dynamic balance between local specialization and large-scale integration. It remains unclear, however, how local changes in functionally specialized areas can influence integrated activity across larger brain networks. By combining transcranial magnetic stimulation with resting-state functional magnetic resonance imaging, we tested for changes in large-scale integration following the application of excitatory or inhibitory stimulation on the human motor cortex. After local inhibitory stimulation, regions encompassing the sensorimotor module concurrently increased their internal integration and decreased their communication with other modules of the brain. There were no such changes in modular dynamics following excitatory stimulation of the same area of motor cortex nor were there changes in the configuration and interactions between core brain hubs after excitatory or inhibitory stimulation of the same area. These results suggest the existence of selective mechanisms that integrate local changes in neural activity, while preserving ongoing communication between brain hubs.
Keyword Connectivity
Brain network
fMRI
Modularity
Connectome
Brain stimulation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
School of Psychology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
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Created: Sun, 19 Apr 2015, 04:17:39 EST by Luca Cocchi on behalf of Queensland Brain Institute