Oxytocin receptor antagonists for inhibiting preterm labour (Review)

Flenady, Vicki, Reinebrant, Hanna E., Liley, Helen G., Tambimuttu, Eashan G. and Papatsonis, Dimitri N. M. (2014) Oxytocin receptor antagonists for inhibiting preterm labour (Review). Cochrane Database of Systematic Reviews, 6: . doi:10.1002/14651858.CD004452.pub3

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Author Flenady, Vicki
Reinebrant, Hanna E.
Liley, Helen G.
Tambimuttu, Eashan G.
Papatsonis, Dimitri N. M.
Title Oxytocin receptor antagonists for inhibiting preterm labour (Review)
Journal name Cochrane Database of Systematic Reviews   Check publisher's open access policy
ISSN 1469-493X
Publication date 2014-06-06
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/14651858.CD004452.pub3
Open Access Status File (Publisher version)
Issue 6
Total pages 105
Place of publication Oxford, United Kingdom
Publisher John Wiley and Sons
Language eng
Abstract Background
Formatted abstract
Preterm birth, defined as birth between 20 and 36 completed weeks, is a major contributor to perinatal morbidity and mortality globally. Oxytocin receptor antagonists (ORA), such as atosiban, have been specially developed for the treatment of preterm labour.  ORA have been proposed as effective tocolytic agents for women in preterm labour to prolong pregnancy with fewer side effects than other tocolytic agents.

To assess the effects on maternal, fetal and neonatal outcomes of tocolysis with ORA for women with preterm labour compared with placebo or any other tocolytic agent. 

Search methods 
We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (1 December 2013). 

Selection criteria
We included all randomised controlled trials (published and unpublished) of ORA for tocolysis of labour between 20 and 36 completed weeks’ gestation.

Data collection and analysis
Two review authors independently evaluated methodological quality and extracted trial data. When required, we sought additional data from trial authors. Results are presented as risk ratio (RR) for categorical and mean difference (MD) for continuous data with the 95% confidence intervals (CI). Where appropriate, the number needed to treat for benefit (NNTB) and the number needed to treat for harm (NNTH) were calculated.
Keyword Double-Blind
Systematic Analysis
Acute Tocolysis
Time Trends
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 38 times in Scopus Article | Citations
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Created: Sat, 11 Apr 2015, 04:13:04 EST by Helen Liley on behalf of Paediatrics & Child Health - Mater Hospital