Effects of left ventricular geometry and obesity on mortality in women with normal ejection fraction

Patel D.A., Lavie C.J., Artham S.M., Milani R.V., Cardenas G.A. and Ventura H.O. (2014) Effects of left ventricular geometry and obesity on mortality in women with normal ejection fraction. American Journal of Cardiology, 113 5: 877-880. doi:10.1016/j.amjcard.2013.11.041

Author Patel D.A.
Lavie C.J.
Artham S.M.
Milani R.V.
Cardenas G.A.
Ventura H.O.
Title Effects of left ventricular geometry and obesity on mortality in women with normal ejection fraction
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
Publication date 2014-03-01
Sub-type Article (original research)
DOI 10.1016/j.amjcard.2013.11.041
Open Access Status Not Open Access
Volume 113
Issue 5
Start page 877
End page 880
Total pages 4
Place of publication New York, NY, U.S.A.
Publisher Elsevier Inc.
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Left ventricular (LV) geometry is an independent predictor of cardiovascular morbidity and mortality. Although obesity is a known risk factor for cardiovascular diseases, studies have suggested a paradoxical relation between obesity and prognosis. We retrospectively assessed 26,126 female patients with normal LV ejection fraction to determine the impact of LV geometry, including normal structure, concentric remodeling, and eccentric or concentric LV hypertrophy, and obesity on mortality during an average follow-up of 1.7 years. Abnormal LV geometry occurred more commonly in obese (body mass index ≥30 kg/m2, n = 10,465) compared with nonobese (body mass index <30 kg/m2, n = 15,661) patients (56% vs 47%, respectively, p <0.0001). Overall mortality, however, was considerably less in obese compared with nonobese patients (5.6% vs 8.7%, respectively, p <0.0001). In both groups, progressive increases in mortality were observed from normal structure to concentric remodeling and then to eccentric and concentric LV hypertrophy (obese patients 2.9%, 6.5%, 6.7%, and 11.1%, respectively, and nonobese patients 5.3%, 10.6%, 11.4%, and 16.8%, respectively, p <0.0001 for trend). In conclusion, although an obesity paradox exists, in that obesity in women is associated with abnormal LV geometry but less mortality, our data demonstrate that abnormal LV geometric patterns are highly prevalent in both obese and nonobese female patients with normal ejection fraction and are associated with greater mortality.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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