Balancing natural killer cell activation through paired receptors

Martinet, Ludovic and Smyth, Mark J. (2015) Balancing natural killer cell activation through paired receptors. Nature Reviews Immunology, 15 4: 243-254. doi:10.1038/nri3799


Author Martinet, Ludovic
Smyth, Mark J.
Title Balancing natural killer cell activation through paired receptors
Journal name Nature Reviews Immunology   Check publisher's open access policy
ISSN 1474-1733
1474-1741
Publication date 2015-03-25
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nri3799
Open Access Status Not yet assessed
Volume 15
Issue 4
Start page 243
End page 254
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections and malignancies. NK cells express a variety of inhibitory and activating receptors that facilitate fine discrimination between damaged and healthy cells. Among them, a family of molecules that bind nectin and nectin-like proteins has recently emerged and has been shown to function as an important regulator of NK cell functions. These molecules include CD226, T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), CD96, and cytotoxic and regulatory T cell molecule (CRTAM). In this Review, we focus on the recent advances in our understanding of how these receptors regulate NK cell biology and of their roles in pathologies such as cancer, infection and autoimmunity.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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