The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study

Shekar, Kiran, Fraser, John F., Taccone, Fabio Silvio, Welch, Susan, Wallis, Steven C., Mullany, Daniel V., Lipman, Jeffrey and Roberts, Jason A. (2014) The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study. Critical Care, 18 6: 1-9. doi:10.1186/s13054-014-0565-2


Author Shekar, Kiran
Fraser, John F.
Taccone, Fabio Silvio
Welch, Susan
Wallis, Steven C.
Mullany, Daniel V.
Lipman, Jeffrey
Roberts, Jason A.
Title The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study
Journal name Critical Care   Check publisher's open access policy
ISSN 1466-609X
1364-8535
Publication date 2014-12-12
Year available 2014
Sub-type Article (original research)
DOI 10.1186/s13054-014-0565-2
Open Access Status DOI
Volume 18
Issue 6
Start page 1
End page 9
Total pages 9
Place of publication London, England, U.K.
Publisher BioMed Central Ltd.
Language eng
Subject 2706 Critical Care and Intensive Care Medicine
Abstract Introduction: The scope of extracorporeal membrane oxygenation (ECMO) is expanding; however, optimal drug prescription during ECMO remains a developing science. Currently, there are no clear guidelines for antibiotic dosing during ECMO. This open-label, descriptive, matched-cohort pharmacokinetics (PK) study aimed to compare the PK of meropenem in ECMO patients to critically ill patients with sepsis not receiving ECMO (controls).
Keyword Critical Care Medicine
General & Internal Medicine
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID APP1048652
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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