Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala

Mahanty, NK and Sah, P (1999) Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala. European Journal of Neuroscience, 11 4: 1217-1222. doi:10.1046/j.1460-9568.1999.00528.x


Author Mahanty, NK
Sah, P
Title Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 0953-816X
Publication date 1999-01-01
Sub-type Article (original research)
DOI 10.1046/j.1460-9568.1999.00528.x
Volume 11
Issue 4
Start page 1217
End page 1222
Total pages 6
Language eng
Abstract Whole-cell patch clamp recordings were made from pyramidal neurons in the rat lateral amygdala (LA). Synaptic currents were evoked by stimulating in either the external capsule (ec), internal capsule (ic) or basolateral nucleus (BLA). Stimulation of either the ic, ec or BLA evoked a glutamatergic excitatory synaptic current (EPSC) which was mediated by both non-NMDA and NMDA (N-methyl-D-aspartic acid) receptors, The ratio of the amplitude of the NMDA receptor-mediated component measured at +40 mV to the amplitude of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) component measured at -60 mV was similar regardless of whether EPSCs were evoked in the ec, ic or BLA. At resting membrane potentials, excitatory synaptic potentials evoked from either the ec or putative thalamic inputs were unaffected by application of the NMDA receptor antagonist APV. Spontaneous glutamatergic currents had two components to their decay phase. The slow component was selectively blocked by the NMDA receptor antagonist D-APV, indicating that AMPA and NMDA receptors are colocalized in spiny neurons. We conclude that pyramidal cells of the LA receive convergent inputs from the cortex, thalamus and basal nuclei. At all inputs, both AMPA/kainate and NMDA-type receptors are active and colocalized in the postsynaptic density.
Keyword Neurosciences
Fear
Gaba
Glutamate
Ltp
Non-nmda Receptors
Phaseolus-vulgaris-leukoagglutinin
Rat Basolateral Amygdala
Long-term Potentiation
Mouse Central Neurons
Hippocampal Slices
Medial Geniculate
Temporal Cortex
Basal Nuclei
Projections
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 21:01:20 EST