The role of HLA in MS susceptibility and phenotype

Greer, Judith M. (2015). The role of HLA in MS susceptibility and phenotype. In Anne C. La Flamme and Jacqueline Monique Orian (Ed.), Emerging and evolving topics in multiple sclerosis pathogenesis and treatments (pp. 1-27) Heidelberg, Germany: Springer. doi:10.1007/7854_2014_357


Author Greer, Judith M.
Title of chapter The role of HLA in MS susceptibility and phenotype
Title of book Emerging and evolving topics in multiple sclerosis pathogenesis and treatments
Place of Publication Heidelberg, Germany
Publisher Springer
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1007/7854_2014_357
Open Access Status Not Open Access
Year available 2014
Series Current Topics in Behavioral Neurosciences
ISBN 9783319255415
9783319255439
ISSN 1866-3370
1866-3389
Editor Anne C. La Flamme
Jacqueline Monique Orian
Volume number 26
Chapter number 1
Start page 1
End page 27
Total pages 27
Total chapters 10
Language eng
Formatted Abstract/Summary
One of the most consistent findings in multiple sclerosis (MS) is that development of MS is linked with carriage of the class II human leucocyte antigen (HLA) molecule HLA-DRB1*15:01; around 60 % of Caucasian MS patients carry this allele compared to 25–30 % of ethnically matched healthy individuals. However, other HLA molecules have also been linked to the development of MS. In this chapter, the association between different HLA types and susceptibility to MS will be reviewed, and other linkages between the carriage of specific HLA molecules and clinical and experimental findings in MS will be considered.
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Fri, 20 Mar 2015, 01:19:14 EST by Roheen Gill on behalf of UQ Centre for Clinical Research