Next generation sequencing applications in head and neck oncology

Farah, Camile S., Jessri, Maryam, Kordbacheh, Farzaneh, Bennett, Nigel C. and Dalley, Andrew (2015). Next generation sequencing applications in head and neck oncology. In Wei Wu and Hani Choudhry (Ed.), Next generation sequencing in cancer research, volume 2: from basepairs to bedside (pp. 401-422) New York, NY, United States: Springer. doi:10.1007/978-3-319-15811-2_23

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Author Farah, Camile S.
Jessri, Maryam
Kordbacheh, Farzaneh
Bennett, Nigel C.
Dalley, Andrew
Title of chapter Next generation sequencing applications in head and neck oncology
Title of book Next generation sequencing in cancer research, volume 2: from basepairs to bedside
Place of Publication New York, NY, United States
Publisher Springer
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1007/978-3-319-15811-2_23
Open Access Status Not yet assessed
Series Next Generation Sequencing in Cancer Research
ISBN 9783319158105
Editor Wei Wu
Hani Choudhry
Volume number 2
Chapter number 23
Start page 401
End page 422
Total pages 22
Total chapters 26
Language eng
Formatted Abstract/Summary
Head and neck cancer remains a major medical problem with significant morbidity, mortality and quality of life issues. Over the recent past there has been an increase in incidence, a shift in etiological factors, a growing proportion of tumours in younger cohorts, and a greater realisation of the heterogeneity of this group of tumours particularly within head and neck squamous cell carcinomas.

The arrival of high-throughput massively parallel sequencing technologies in diagnostic laboratories heralds an opportunity for uncovering driver mutations in head and neck cancer, understanding of disease stratification, personalisation of treatment strategies within the framework of genomic medicine, and discovery of potential druggable targets for disease-specific treatment.

Next-generation sequencing (NGS) is a powerful tool and has the potential to transform the reactive and treatment-based nature of cancer care, to actively predict the risk for disease and aim to prevent it. The underlying goal of NGS application is to achieve the concept of “genome-informed personalised medicine”. An important factor in harnessing NGS technologies in personalised management of head and neck oncology lies in the feedback between scientists and clinicians involved in cancer care. A genuine diagnosis and appropriate aetiology-matched treatment is only possible if our decisions are based on both the genotype and phenotype of our patients.
Keyword Massively parallel sequencing
Next-generation sequencing
Head and neck cancer
Clinical oncology
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: UQ Centre for Clinical Research Publications
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Created: Fri, 20 Mar 2015, 01:05:56 EST by Roheen Gill on behalf of UQ Centre for Clinical Research