Lung cancer-initiating cells: A novel target for cancer therapy

Morrison, Brian J., Morris, John C. and Steel, Jason C. (2013) Lung cancer-initiating cells: A novel target for cancer therapy. Targeted Oncology, 8 3: 159-172. doi:10.1007/s11523-012-0247-4

Author Morrison, Brian J.
Morris, John C.
Steel, Jason C.
Title Lung cancer-initiating cells: A novel target for cancer therapy
Journal name Targeted Oncology   Check publisher's open access policy
ISSN 1776-2596
Publication date 2013-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11523-012-0247-4
Open Access Status DOI
Volume 8
Issue 3
Start page 159
End page 172
Total pages 14
Place of publication Paris, France
Publisher Springer France
Language eng
Abstract Lung cancer is a major public health problem causing more deaths than any other cancer. A better understanding of the biology of this disease and improvements in treatment are greatly needed. Increasing evidence supports the concept that a rare and specialized population of cancer cells, so-called cancer-initiating cells with stem cell-like characteristics, is responsible for tumor growth, maintenance, and recurrence. Cancer-initiating cells also exhibit characteristics that render them resistant to both radiation and chemotherapy, and therefore they are believed to play a role in treatment failure. This has led to the hypothesis that traditional therapies that indiscriminately kill tumor cells will not be as effective as therapies that selectively target cancer-initiating cells. Investigating putative cancer-initiating cells in lung cancer will greatly benefit the understanding of the origins of this disease and may lead to novel approaches to therapy by suggesting markers for use in either further isolating this population for study or for selectively targeting these cells. This review will discuss (1) lung cancer, (2) stem cells, and the role of cancer-initiating cells in tumorigenesis; (3) markers and functional characteristics associated with lung cancer-initiating cells; and (4) the potential to selectively target this subpopulation of tumor cells.
Keyword Cancer
Cancer-initiating cells
Stem cells
Targeted therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Wed, 18 Mar 2015, 02:01:32 EST by Jason Steel on behalf of Medicine - Greenslopes Private Hospital