Current smoking is a risk factor for incident ankylosing spondylitis – HUNT population-based Norwegian health study.

Videm, Vibeke, Cortes, Adrian, Thomas, Ranjeny and Brown, Matthew A. (2014) Current smoking is a risk factor for incident ankylosing spondylitis – HUNT population-based Norwegian health study.. Journal of Rheumatology, 41 10: 2041-2048. doi:10.3899/jrheum.140353


Author Videm, Vibeke
Cortes, Adrian
Thomas, Ranjeny
Brown, Matthew A.
Title Current smoking is a risk factor for incident ankylosing spondylitis – HUNT population-based Norwegian health study.
Journal name Journal of Rheumatology   Check publisher's open access policy
ISSN 0315-162X
1499-2752
Publication date 2014-10-01
Year available 2014
Sub-type Article (original research)
DOI 10.3899/jrheum.140353
Volume 41
Issue 10
Start page 2041
End page 2048
Total pages 8
Place of publication Toronto, ON, Canada
Publisher Journal of Rheumatology Publishing
Language eng
Formatted abstract
Objective. Smoking contributes to progression of ankylosing spondylitis (AS). Because smoking is also a risk factor for incident rheumatoid arthritis (RA) and psoriatic arthritis, our aim was to test whether smoking habits are associated with incident AS.

Methods. Using data from the HUNT health study of the entire adult population of Nord-Trøndelag, Norway, participants in HUNT2 (1995–1997) and HUNT3 (2006–2008) were identified who reported a diagnosis of AS in HUNT3 but not in HUNT2 (n = 107). Incident AS cases were compared with AS-unaffected individuals (n = 35,278) in a case-control design. Participants with RA were excluded.

Results. Present smoking was significantly associated with incident self-reported AS in logistic regression adjusted for potential confounders (OR 1.99, 95% CI 1.28–3.11, p = 0.002). Previous smoking (OR 1.15, 95% CI 0.66–2.02, p = 0.62) or total pack-years at HUNT2 (OR 1.01, 95% CI 0.99–1.04, p = 0.21) were not significant. The association with present smoking remained significant in various sensitivity analyses: including only cases with high probability of true AS diagnosis (OR 1.82, 95% CI 1.03–3.19, p = 0.04); including only cases with AS reported more than 3–5 years after HUNT2 (OR 2.34, 95% CI 1.09–5.03, p = 0.029), or including only participants genotyped for HLA-B27 (94 cases and 859 controls) adjusting for genotype (OR 1.79, 95% CI 1.04–2.85, p = 0.033). Hypertension was also significantly associated with incident AS (OR from 1.65 to 2.81).

Conclusion. In the HUNT population-based study, incident AS was associated with current smoking and hypertension. If verified in further studies, this suggests that smoking should be discouraged in those at a higher AS risk, e.g., with a family history or carrying HLA-B27.
Keyword Ankylosing spondylitis
Axial spondyloarthritis
Smoking
Epidemiology
Risk factor
HUNT
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
UQ Diamantina Institute Publications
 
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Created: Fri, 13 Mar 2015, 18:40:24 EST by Professor Ranjeny Thomas on behalf of UQ Diamantina Institute