Role of maintenance treatment in opioid dependence

Ward, Jeff, Hall, Wayne and Mattick, Richard P. (1999) Role of maintenance treatment in opioid dependence. Lancet, 353 9148: 221-226. doi:10.1016/S0140-6736(98)05356-2

Author Ward, Jeff
Hall, Wayne
Mattick, Richard P.
Title Role of maintenance treatment in opioid dependence
Journal name Lancet   Check publisher's open access policy
ISSN 0140-6736
Publication date 1999-01-01
Year available 1999
Sub-type Article (original research)
DOI 10.1016/S0140-6736(98)05356-2
Open Access Status Not yet assessed
Volume 353
Issue 9148
Start page 221
End page 226
Total pages 6
Place of publication London
Publisher Lancet Publishing Group
Language eng
Abstract Methadone maintenance treatment (MMT) involves the daily administration of the oral opioid agonist methadone as a treatment for opioid dependence-a persistent disorder with a substantial risk of premature death. MMT improves health and reduces illicit heroin use, infectious-disease transmission, and overdose death. However, its effectiveness is compromised if low maintenance doses of methadone (<60 mg) are used and patients are pressured to become prematurely abstinent from methadone. Pregnancy and psychiatric comorbidity are not contraindications for MMT. As an alternative to MMT, other oral opioid agents (eg, naltrexone, buprenorphine) may increase patient choice and avoid some of the more unpleasant aspects of MMT. The public-health challenge for the future is to develop and continue to deliver safe and effective forms of opioid maintenance treatment to as many opioid-dependent individuals as can benefit from them.
Keyword Medicine, General & Internal
Controlled Trial
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 272 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 316 times in Scopus Article | Citations
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Created: Mon, 13 Aug 2007, 20:52:20 EST