Genetic basis and detection of unintended effects in genetically modified crop plants

Ladics, Gregory S., Bartholomaeus, Andrew, Bregitzer, Phil, Doerrer, Nancy G., Gray, Alan, Holzhauser, Thomas, Jordan, Mark, Keese, Paul, Kok, Esther, Macdonald, Phil, Parrott, Wayne, Privalle, Laura, Raybould, Alan, Rhee, Seung Yon, Rice, Elena, Romeis, Jorg, Vaughn, Justin, Wal, Jean-Michel and Glenn, Kevin (2015) Genetic basis and detection of unintended effects in genetically modified crop plants. Transgenic Research, 24 4: 587-603. doi:10.1007/s11248-015-9867-7

Author Ladics, Gregory S.
Bartholomaeus, Andrew
Bregitzer, Phil
Doerrer, Nancy G.
Gray, Alan
Holzhauser, Thomas
Jordan, Mark
Keese, Paul
Kok, Esther
Macdonald, Phil
Parrott, Wayne
Privalle, Laura
Raybould, Alan
Rhee, Seung Yon
Rice, Elena
Romeis, Jorg
Vaughn, Justin
Wal, Jean-Michel
Glenn, Kevin
Title Genetic basis and detection of unintended effects in genetically modified crop plants
Journal name Transgenic Research   Check publisher's open access policy
ISSN 0962-8819
Publication date 2015-02-26
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11248-015-9867-7
Open Access Status DOI
Volume 24
Issue 4
Start page 587
End page 603
Total pages 17
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Formatted abstract
In January 2014, an international meeting sponsored by the International Life Sciences Institute/Health and Environmental Sciences Institute and the Canadian Food Inspection Agency titled “Genetic Basis of Unintended Effects in Modified Plants” was held in Ottawa, Canada, bringing together over 75 scientists from academia, government, and the agro-biotech industry. The objectives of the meeting were to explore current knowledge and identify areas requiring further study on unintended effects in plants and to discuss how this information can inform and improve genetically modified (GM) crop risk assessments. The meeting featured presentations on the molecular basis of plant genome variability in general, unintended changes at the molecular and phenotypic levels, and the development and use of hypothesis-driven evaluations of unintended effects in assessing conventional and GM crops. The development and role of emerging “omics” technologies in the assessment of unintended effects was also discussed. Several themes recurred in a number of talks; for example, a common observation was that no system for genetic modification, including conventional methods of plant breeding, is without unintended effects. Another common observation was that “unintended” does not necessarily mean “harmful”. This paper summarizes key points from the information presented at the meeting to provide readers with current viewpoints on these topics.
Keyword Unintended effects
GM crop plants
Environmental risk assessment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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