The Pain and Opioids IN Treatment study: characteristics of a cohort using opioids to manage chronic non-cancer pain

Campbell, Gabrielle, Nielsen, Suzanne, Bruno, Raimondo, Liptzeris, Nicholas, Cohen, Milton, Hall, Wayne, Larance, Briony, Mattick, Richard P. and Degenhardt, Louisa (2015) The Pain and Opioids IN Treatment study: characteristics of a cohort using opioids to manage chronic non-cancer pain. Pain, 156 2: 231-242. doi:10.1097/01.j.pain.0000460303.63948.8e

Author Campbell, Gabrielle
Nielsen, Suzanne
Bruno, Raimondo
Liptzeris, Nicholas
Cohen, Milton
Hall, Wayne
Larance, Briony
Mattick, Richard P.
Degenhardt, Louisa
Title The Pain and Opioids IN Treatment study: characteristics of a cohort using opioids to manage chronic non-cancer pain
Journal name Pain   Check publisher's open access policy
ISSN 0304-3959
Publication date 2015-02-01
Year available 2015
Sub-type Article (original research)
DOI 10.1097/01.j.pain.0000460303.63948.8e
Open Access Status Not Open Access
Volume 156
Issue 2
Start page 231
End page 242
Total pages 12
Place of publication Philadelphia, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract There has been a recent increase in public and professional concern about the prescription of strong prescription opioids for pain. Despite this concern, research to date has been limited because of a number of factors such as small sample sizes, exclusion of people with complex comorbidities, and studies of short duration. The Pain and Opioids IN Treatment is a 2-year prospective cohort study of 1500 people prescribed with pharmaceutical opioids for their chronic pain. This article provides an overview of the demographic and clinical characteristics of the cohort using the baseline data of 1514 community-based people across Australia. Participants had been in pain for a period of 10 years and had been on prescription opioids for approximately 4 years. One in 10 was on a daily morphine equivalent dose of >=200 mg. Employment and income levels were low, and two-thirds of the sample reported that their pain had impacted on their employment status. Approximately 50% screened positive for current moderate-to-severe depression, and 1 in 5 had made a lifetime suicide attempt. There were a number of age-related differences. The younger groups experienced higher levels of pain and pain interference, more mental health and substance use issues, and barriers to treatment, compared with the older group. This study found that the people who have been prescribed strong opioids for chronic pain have very complex demographic and clinical profiles. Major age-related differences in the experiences of pain, coping, mental health, and substance use suggest the necessity of differential approaches to treatment.
Keyword Chronic non-cancer pain
International neuropsychiatric interview
Quality of life
United States
Immpact recommendations
Clinical trials
Older adults
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 1022522
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Centre for Youth Substance Abuse Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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