Genetic studies of body mass index yield new insights for obesity biology

Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jian'an, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Zhao, Jing Hua, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Asa K., Karjalainen, Juha, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L., Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Leach, Irene Mateo, Medina-Gomez, Carolina, Medland, Sarah E., Nalls, Michael A., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Shungin, Dmitry, Stančáková, Alena, Strawbridge, Rona J., Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W., van Settee, Jessica, Van Vliet-Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Attwood, Antony P., Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N., Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blagieva, Roza, Blüher, Matthias, Böhringer, Stefan, Bonnycastle, Lori L., Böttcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Caspersen, Ida H., Chen, Yii-Der Ida, Clarke, Robert, Daw, E. Warwick, de Craen, Anton J. M., Delgado, Graciela, Dimitriou, Maria, Doney, Alex S. F., Eklund, Niina, Estrada, Karol, Eury, Elodie, Folkersen, Lasse, Fraser, Ross M., Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Goodall, Alison H., Gordon, Scott D., Gorski, Mathias, Grabe, Hans-Jörgen, Grallert, Harald, Grammer, Tanja B., Gräßler, Jürgen, Grönberg, Henrik, Groves, Christopher J., Gusto, Gaëlle, Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L., Helmer, Qinta, Hengstenberg, Christian, Holmen, Oddgeir, Hottenga, Jouke-Jan, James, Alan L., Jeff, Janina M., Johansson, Åsa, Jolley, Jennifer, Juliusdottir, Thorhildur, Kinnunen, Leena, Koenig, Wolfgang, Koskenvuo, Markku, Kratzer, Wolfgang, Laitinen, Jaana, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lo, Ken Sin, Lobbens, Stéphane, Lorbeer, Roberto, Lu, Yingchang, Mach, Francois, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., McLachlan, Stela, Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Musk, Arthur W., Nagaraja, Ramaiah, Nöthen, Markus M., Nolte, Ilja M., Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Rettig, Rainer, Ried, Janina S., Ripke, Stephan, Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Scott, William R., Seufferlein, Thomas, Shi, Jianxin, Smith, Albert Vernon, Smolonska, Joanna, Stanton, Alice V., Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvanen, Ann-Christine, Tan, Sian-Tsung, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tyrer, Jonathan P., Uh, Hae-Won, Vandenput, Liesbeth, Verhulst, Frank C., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Warren, Helen R., Waterworth, Dawn, Weedon, Michael N., Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wright, Alan F, Zhang, Qunyuan, Brennan, Eoin P., Choi, Murim, Dastani, Zari, Drong, Alexander W., Eriksson, Per, Franco-Cereceda, Anders, Gådin, Jesper R., Gharavi, Ali G., Goddard, Michael E., Handsaker, Robert E., Huang, Jinyan, Karpe, Fredrik, Kathiresan, Sekar, Keildson, Sarah, Kiryluk, Krzysztof, Kubo, Michiaki, Lee, Jong-Young, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McCarroll, Steven A., McKnight, Amy J., Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Okada, Yukinori, Perry, John R. B., Dorajoo, Rajkumar, Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Scott, Robert A., Stolk, Lisette, Takahashi, Atsushi, Tanaka, Toshihiro, van 't Hooft, Ferdinand M., Vinkhuyzen, Anna A. E., Westra, Harm-Jan, Zheng, Wei, Zondervan, Krina T., Heath, Andrew C., Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Bovet, Pascal, Campbell, Harry, Caulfield, Mark J., Cesana, Giancarlo, Chakravarti, Aravinda, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Crawford, Dana C., Cupples, L. Adrienne, Cusi, Daniele, Danesh, John, de Faire, Ulf, den Ruijter, Hester M., Dominiczak, Anna F., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Felix, Stephan B., Ferrannini, Ele, Ferrieres, Jean, Ferrieres, Jean, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Franco, Oscar H., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Gudnason, Vilmundur, Gudnason, Vilmundur, Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Hicks, Andrew A, Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Homuth, Georg, Hovingh, G. Kees, Humphries, Steve E., Hunt, Steven C., Hypponen, Elina, Illig, Thomas, Jacobs, Kevin B., Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Johansen, Berit, Jousilahti, Pekka, Jukema, J. Wouter, Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Knekt, Paul, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Laic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Moll, Frans L., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Madden, Pamela A. F., Pasterkamp, Gerard, Peden, John F., Peters, Annette, Postma, Dirkje S., Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Rioux, John D., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramines, Jouko, Sarzynski, Mark A., Schunkert, Heribert, Schwarz, Peter E. H., Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Trégouët, David-Alexandre, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Völker, Uwe, Waeber, Gérard, Willemsen, Gonneke, Witteman, Jacqueline C., Zillikens, M. Carola, Adair, Linda S., Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murielle, Boehm, Bernhard O., Boerwinkle, Eric, Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stephane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., de Bakker, Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Anders, Hui, Jennie, Hunter, David J., Hveem, Kristian, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., März, Winfried, Melbye, Mads, Metspalu, Andres, Moebus, Susanne, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Schadt, Eric E., Schlessinger, David, Slagboom, P. Eline, Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wichmann, H-Erich, Wilson, James F., Zanen, Pieter, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Heid, Iris M., O'Connell, Jeffrey R., Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Abecasis, Gonçalo R., Franke, Lude, Frayling, Timothy M., McCarthy, Mark I., Visscher, Peter M., Scherag, André, Willer, Cristen J., Boehnke, Michael, Mohlke, Karen L., Lindgren, Cecilia M., Beckmann, Jacques S., Barroso, Inês, North, Kari E., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F., Speliotes, Elizabeth K., The ADIPOGen Consortium, The AGEN-BMI Working Group, The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GLGC, The ICBP, The MAGIC Investigators, The MuTHER Consortium, The MIGen Consortium, The PAGE Consortium, The ReproGen Consortium, The GENIE Consortium, The International Endogene Consortium, Byrne, Enda M., Lee, Sang Hong and Treloar, Susan A. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 7538: 197-206. doi:10.1038/nature14177

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Author Locke, Adam E.
Kahali, Bratati
Berndt, Sonja I.
Justice, Anne E.
Pers, Tune H.
Day, Felix R.
Powell, Corey
Vedantam, Sailaja
Buchkovich, Martin L.
Yang, Jian
Croteau-Chonka, Damien C.
Esko, Tonu
Fall, Tove
Ferreira, Teresa
Gustafsson, Stefan
Kutalik, Zoltán
Luan, Jian'an
Mägi, Reedik
Randall, Joshua C.
Winkler, Thomas W.
Wood, Andrew R.
Workalemahu, Tsegaselassie
Faul, Jessica D.
Smith, Jennifer A.
Zhao, Jing Hua
Zhao, Wei
Chen, Jin
Fehrmann, Rudolf
Hedman, Asa K.
Karjalainen, Juha
Schmidt, Ellen M.
Absher, Devin
Amin, Najaf
Anderson, Denise
Beekman, Marian
Bolton, Jennifer L.
Bragg-Gresham, Jennifer L.
Buyske, Steven
Demirkan, Ayse
Deng, Guohong
Ehret, Georg B.
Feenstra, Bjarke
Feitosa, Mary F.
Fischer, Krista
Goel, Anuj
Gong, Jian
Jackson, Anne U.
Kanoni, Stavroula
Kleber, Marcus E.
Kristiansson, Kati
Lim, Unhee
Lotay, Vaneet
Mangino, Massimo
Leach, Irene Mateo
Medina-Gomez, Carolina
Medland, Sarah E.
Nalls, Michael A.
Palmer, Cameron D.
Pasko, Dorota
Pechlivanis, Sonali
Peters, Marjolein J.
Prokopenko, Inga
Shungin, Dmitry
Stančáková, Alena
Strawbridge, Rona J.
Sung, Yun Ju
Tanaka, Toshiko
Teumer, Alexander
Trompet, Stella
van der Laan, Sander W.
van Settee, Jessica
Van Vliet-Ostaptchouk, Jana V.
Wang, Zhaoming
Yengo, Loïc
Zhang, Weihua
Isaacs, Aaron
Albrecht, Eva
Ärnlöv, Johan
Arscott, Gillian M.
Attwood, Antony P.
Bandinelli, Stefania
Barrett, Amy
Bas, Isabelita N.
Bellis, Claire
Bennett, Amanda J.
Berne, Christian
Blagieva, Roza
Blüher, Matthias
Böhringer, Stefan
Bonnycastle, Lori L.
Böttcher, Yvonne
Boyd, Heather A.
Bruinenberg, Marcel
Caspersen, Ida H.
Chen, Yii-Der Ida
Clarke, Robert
Daw, E. Warwick
de Craen, Anton J. M.
Delgado, Graciela
Dimitriou, Maria
Doney, Alex S. F.
Eklund, Niina
Estrada, Karol
Eury, Elodie
Folkersen, Lasse
Fraser, Ross M.
Garcia, Melissa E.
Geller, Frank
Giedraitis, Vilmantas
Gigante, Bruna
Go, Alan S.
Golay, Alain
Goodall, Alison H.
Gordon, Scott D.
Gorski, Mathias
Grabe, Hans-Jörgen
Grallert, Harald
Grammer, Tanja B.
Gräßler, Jürgen
Grönberg, Henrik
Groves, Christopher J.
Gusto, Gaëlle
Haessler, Jeffrey
Hall, Per
Haller, Toomas
Hallmans, Goran
Hartman, Catharina A.
Hassinen, Maija
Hayward, Caroline
Heard-Costa, Nancy L.
Helmer, Qinta
Hengstenberg, Christian
Holmen, Oddgeir
Hottenga, Jouke-Jan
James, Alan L.
Jeff, Janina M.
Johansson, Åsa
Jolley, Jennifer
Juliusdottir, Thorhildur
Kinnunen, Leena
Koenig, Wolfgang
Koskenvuo, Markku
Kratzer, Wolfgang
Laitinen, Jaana
Lamina, Claudia
Leander, Karin
Lee, Nanette R.
Lichtner, Peter
Lind, Lars
Lindström, Jaana
Lo, Ken Sin
Lobbens, Stéphane
Lorbeer, Roberto
Lu, Yingchang
Mach, Francois
Magnusson, Patrik K. E.
Mahajan, Anubha
McArdle, Wendy L.
McLachlan, Stela
Menni, Cristina
Merger, Sigrun
Mihailov, Evelin
Milani, Lili
Moayyeri, Alireza
Monda, Keri L.
Morken, Mario A.
Mulas, Antonella
Müller, Gabriele
Müller-Nurasyid, Martina
Musk, Arthur W.
Nagaraja, Ramaiah
Nöthen, Markus M.
Nolte, Ilja M.
Pilz, Stefan
Rayner, Nigel W.
Renstrom, Frida
Rettig, Rainer
Ried, Janina S.
Ripke, Stephan
Robertson, Neil R.
Rose, Lynda M.
Sanna, Serena
Scharnagl, Hubert
Scholtens, Salome
Schumacher, Fredrick R.
Scott, William R.
Seufferlein, Thomas
Shi, Jianxin
Smith, Albert Vernon
Smolonska, Joanna
Stanton, Alice V.
Steinthorsdottir, Valgerdur
Stirrups, Kathleen
Stringham, Heather M.
Sundström, Johan
Swertz, Morris A.
Swift, Amy J.
Syvanen, Ann-Christine
Tan, Sian-Tsung
Tayo, Bamidele O.
Thorand, Barbara
Thorleifsson, Gudmar
Tyrer, Jonathan P.
Uh, Hae-Won
Vandenput, Liesbeth
Verhulst, Frank C.
Vermeulen, Sita H.
Verweij, Niek
Vonk, Judith M.
Waite, Lindsay L.
Warren, Helen R.
Waterworth, Dawn
Weedon, Michael N.
Wilkens, Lynne R.
Willenborg, Christina
Wilsgaard, Tom
Wojczynski, Mary K.
Wong, Andrew
Wright, Alan F
Zhang, Qunyuan
Brennan, Eoin P.
Choi, Murim
Dastani, Zari
Drong, Alexander W.
Eriksson, Per
Franco-Cereceda, Anders
Gådin, Jesper R.
Gharavi, Ali G.
Goddard, Michael E.
Handsaker, Robert E.
Huang, Jinyan
Karpe, Fredrik
Kathiresan, Sekar
Keildson, Sarah
Kiryluk, Krzysztof
Kubo, Michiaki
Lee, Jong-Young
Liang, Liming
Lifton, Richard P.
Ma, Baoshan
McCarroll, Steven A.
McKnight, Amy J.
Min, Josine L.
Moffatt, Miriam F.
Montgomery, Grant W.
Murabito, Joanne M.
Nicholson, George
Nyholt, Dale R.
Okada, Yukinori
Perry, John R. B.
Dorajoo, Rajkumar
Reinmaa, Eva
Salem, Rany M.
Sandholm, Niina
Scott, Robert A.
Stolk, Lisette
Takahashi, Atsushi
Tanaka, Toshihiro
van 't Hooft, Ferdinand M.
Vinkhuyzen, Anna A. E.
Westra, Harm-Jan
Zheng, Wei
Zondervan, Krina T.
Heath, Andrew C.
Arveiler, Dominique
Bakker, Stephan J. L.
Beilby, John
Bergman, Richard N.
Blangero, John
Bovet, Pascal
Campbell, Harry
Caulfield, Mark J.
Cesana, Giancarlo
Chakravarti, Aravinda
Chasman, Daniel I.
Chines, Peter S.
Collins, Francis S.
Crawford, Dana C.
Cupples, L. Adrienne
Cusi, Daniele
Danesh, John
de Faire, Ulf
den Ruijter, Hester M.
Dominiczak, Anna F.
Erbel, Raimund
Erdmann, Jeanette
Eriksson, Johan G.
Farrall, Martin
Felix, Stephan B.
Ferrannini, Ele
Ferrieres, Jean
Ferrieres, Jean
Forouhi, Nita G.
Forrester, Terrence
Franco, Oscar H.
Franco, Oscar H.
Gejman, Pablo V.
Gieger, Christian
Gottesman, Omri
Gudnason, Vilmundur
Gudnason, Vilmundur
Hall, Alistair S.
Harris, Tamara B.
Hattersley, Andrew T.
Hicks, Andrew A
Hindorff, Lucia A.
Hingorani, Aroon D.
Hofman, Albert
Homuth, Georg
Hovingh, G. Kees
Humphries, Steve E.
Hunt, Steven C.
Hypponen, Elina
Illig, Thomas
Jacobs, Kevin B.
Jarvelin, Marjo-Riitta
Jöckel, Karl-Heinz
Johansen, Berit
Jousilahti, Pekka
Jukema, J. Wouter
Jula, Antti M.
Kaprio, Jaakko
Kastelein, John J. P.
Keinanen-Kiukaanniemi, Sirkka M.
Kiemeney, Lambertus A.
Knekt, Paul
Kooner, Jaspal S.
Kooperberg, Charles
Kovacs, Peter
Kraja, Aldi T.
Kumari, Meena
Kuusisto, Johanna
Lakka, Timo A.
Langenberg, Claudia
Le Marchand, Laic
Lehtimäki, Terho
Lyssenko, Valeriya
Männistö, Satu
Marette, André
Matise, Tara C.
McKenzie, Colin A.
McKnight, Barbara
Moll, Frans L.
Morris, Andrew D.
Morris, Andrew P.
Murray, Jeffrey C.
Nelis, Mari
Ohlsson, Claes
Oldehinkel, Albertine J.
Ong, Ken K.
Madden, Pamela A. F.
Pasterkamp, Gerard
Peden, John F.
Peters, Annette
Postma, Dirkje S.
Pramstaller, Peter P.
Price, Jackie F.
Qi, Lu
Raitakari, Olli T.
Rankinen, Tuomo
Rao, D. C.
Rice, Treva K.
Ridker, Paul M.
Rioux, John D.
Ritchie, Marylyn D.
Rudan, Igor
Salomaa, Veikko
Samani, Nilesh J.
Saramines, Jouko
Sarzynski, Mark A.
Schunkert, Heribert
Schwarz, Peter E. H.
Sever, Peter
Shuldiner, Alan R.
Sinisalo, Juha
Stolk, Ronald P.
Strauch, Konstantin
Tönjes, Anke
Trégouët, David-Alexandre
Tremblay, Angelo
Tremoli, Elena
Virtamo, Jarmo
Vohl, Marie-Claude
Völker, Uwe
Waeber, Gérard
Willemsen, Gonneke
Witteman, Jacqueline C.
Zillikens, M. Carola
Adair, Linda S.
Amouyel, Philippe
Asselbergs, Folkert W.
Assimes, Themistocles L.
Bochud, Murielle
Boehm, Bernhard O.
Boerwinkle, Eric
Bornstein, Stefan R.
Bottinger, Erwin P.
Bouchard, Claude
Cauchi, Stephane
Chambers, John C.
Chanock, Stephen J.
Cooper, Richard S.
de Bakker, Paul I. W.
Dedoussis, George
Ferrucci, Luigi
Franks, Paul W.
Froguel, Philippe
Groop, Leif C.
Haiman, Christopher A.
Hamsten, Anders
Hui, Jennie
Hunter, David J.
Hveem, Kristian
Kaplan, Robert C.
Kivimaki, Mika
Kuh, Diana
Laakso, Markku
Liu, Yongmei
Martin, Nicholas G.
März, Winfried
Melbye, Mads
Metspalu, Andres
Moebus, Susanne
Munroe, Patricia B.
Njølstad, Inger
Oostra, Ben A.
Palmer, Colin N. A.
Pedersen, Nancy L.
Perola, Markus
Pérusse, Louis
Peters, Ulrike
Power, Chris
Quertermous, Thomas
Rauramaa, Rainer
Rivadeneira, Fernando
Saaristo, Timo E.
Saleheen, Danish
Sattar, Naveed
Schadt, Eric E.
Schlessinger, David
Slagboom, P. Eline
Snieder, Harold
Spector, Tim D.
Thorsteinsdottir, Unnur
Stumvoll, Michael
Tuomilehto, Jaakko
Uitterlinden, André G.
Uusitupa, Matti
van der Harst, Pim
Walker, Mark
Wallaschofski, Henri
Wareham, Nicholas J.
Watkins, Hugh
Weir, David R.
Wichmann, H-Erich
Wilson, James F.
Zanen, Pieter
Borecki, Ingrid B.
Deloukas, Panos
Fox, Caroline S.
Heid, Iris M.
O'Connell, Jeffrey R.
Strachan, David P.
Stefansson, Kari
van Duijn, Cornelia M.
Abecasis, Gonçalo R.
Franke, Lude
Frayling, Timothy M.
McCarthy, Mark I.
Visscher, Peter M.
Scherag, André
Willer, Cristen J.
Boehnke, Michael
Mohlke, Karen L.
Lindgren, Cecilia M.
Beckmann, Jacques S.
Barroso, Inês
North, Kari E.
Ingelsson, Erik
Hirschhorn, Joel N.
Loos, Ruth J. F.
Speliotes, Elizabeth K.
The ADIPOGen Consortium
The AGEN-BMI Working Group
The CARDIOGRAMplusC4D Consortium
The CKDGen Consortium
The GLGC
The ICBP
The MAGIC Investigators
The MuTHER Consortium
The MIGen Consortium
The PAGE Consortium
The ReproGen Consortium
The GENIE Consortium
The International Endogene Consortium
Byrne, Enda M.
Lee, Sang Hong
Treloar, Susan A.
Title Genetic studies of body mass index yield new insights for obesity biology
Journal name Nature   Check publisher's open access policy
ISSN 1476-4687
0028-0836
Publication date 2015-02-12
Year available 2015
Sub-type Article (original research)
DOI 10.1038/nature14177
Open Access Status Not yet assessed
Volume 518
Issue 7538
Start page 197
End page 206
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Formatted abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Keyword Body mass index (BMI)
Obesity
Genetic analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01 DK093757
MC_UU_12012/1
CZB/4/710
G9521010
G1001799
CZB/4/672
K23 DK080145
098017
R21 DA027040
U01 HG007419
R01 NS017950
MRC_MC_UU_12013/1
RG/08/008/25291
BHF_FS/14/55/30806
T32 GM007814
WT098017
MRC_G9521010
MRC_MR/K013351/1
MRC_MC_UU_12015/5
R01 HL109946
MC_UP_A100_1003
WT098381
T32 GM080178
U01 AG009740
085235
MRC_MR/N01104X/1
U01 HG007416
MRC_MC_UU_12015/2
RG/08/014/24067
R01 DK072193
MC_UU_12019/1
G1000143
U01 HG007376
BHF_RG/10/12/28456
R01 DK075787
MRC_MC_UP_A100_1003
UL1 TR000124
MR/L003120/1
R01 AG025941
R01 AG041517
MC_UU_12015/1
R01 DK062370
R01 HL105756
MRC_G1000143
MRC_MC_UU_12019/1
MC_U106179471
MR/N01104X/1
P30 DK063491
097117
MC_UU_12015/2
TL1 TR001066
T32 HL007824
P20 MD006899
P30 DK072488
WT084766
K01 HL116770
14136
WT100574
CSO_CZB/4/672
MC_U106179472
R01 AG033193
G0401527
CSO_CZB/4/710
MRC_MC_PC_U127561128
MC_UU_12013/1
P30 DK020541
MC_PC_U127561128
UM1 CA182913
CRUK_14136
U01 DK062370
P30 HL107251
MRC_MR/K006584/1
084766
100574
P30 GM103341
R01 DK089256
FS/14/55/30806
MRC_G0401527
MR/K006584/1
MR/K013351/1
MRC_MC_UU_12015/1
P30 DK020572
MC_UU_12015/5
P60 DK020541
BHF_RG/08/014/24067
R01 HL117626
MRC_MC_U106179471
BHF_RG/08/008/25291
098381
R01 HL117078
MRC_MR/L003120/1
WT085235
UM1 CA182910
T32 HL007055
MRC_G0601261
G0601261
P30 CA071789
WT097117
MRC_G1001799
R01 DK078150
MRC_MC_U106179472
MRC_MC_UU_12012/1
UL1 TR001067
RG/10/12/28456
U01 AG049505
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
UQ Diamantina Institute Publications
 
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