Reporting of patient-centred outcomes in heart failure trials: are patient preferences being ignored?

Blom, Jeanet W., El Azzi, Maya, Wopereis, Daisy M., Glynn, Liam, Muth, Christiane and van Driel, Mieke L. (2015) Reporting of patient-centred outcomes in heart failure trials: are patient preferences being ignored?. Heart Failure Reviews, 20 4: 385-392. doi:10.1007/s10741-015-9476-9

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Author Blom, Jeanet W.
El Azzi, Maya
Wopereis, Daisy M.
Glynn, Liam
Muth, Christiane
van Driel, Mieke L.
Title Reporting of patient-centred outcomes in heart failure trials: are patient preferences being ignored?
Journal name Heart Failure Reviews   Check publisher's open access policy
ISSN 1573-7322
Publication date 2015-07-01
Year available 2015
Sub-type Article (original research)
DOI 10.1007/s10741-015-9476-9
Open Access Status DOI
Volume 20
Issue 4
Start page 385
End page 392
Total pages 8
Place of publication New York, NY United States
Publisher Springer New York
Language eng
Abstract Older people often suffer from multiple diseases. Therefore, universal cross-disease outcomes (e.g. functional status, quality of life, overall survival) are more relevant than disease-specific outcomes, and a range of potential outcomes are needed for medical decision-making. To assess how patient-relevant outcomes have penetrated randomized controlled trials (RCTs), reporting of these outcomes was reviewed in heart failure trials that included patients with multimorbidity. We systematically reviewed RCTs (Jan 2011–June 2012) and evaluated reported outcomes. Heart failure was chosen as condition of interest as this is common among older patients with multimorbidity. The main outcome was the proportion of RCTs reporting all-cause mortality, all-cause hospital admission, and outcomes in four domains of health, i.e. functional, signs and symptoms, psychological, and social domains. Of the 106 included RCTs, 50 (47 %) reported all-cause mortality and cardiovascular mortality and 29 (27 %) reported all-cause hospitalization and cardiovascular hospitalization. Of all trials, 68 (64 %) measured outcomes in the functional domain, 80 (75 %) in the domain of signs and symptoms, 65 (61 %) in the psychological domain, and 59 (56 %) in the social domain. Disease-specific instruments were more often used than non-disease-specific instruments. This review shows increasing attention for more patient-relevant outcomes; this is promising and indicates more awareness of the importance of a variety of outcomes desirable for patients. However, patients’ individual goal attainments were universally absent. For continued progress in patient-centred care, efforts are needed to develop these outcomes, study their merits and pitfalls, and intensify their use in research.
Keyword Heart failure
Patient-reported outcomes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Discipline of General Practice Publications
Official 2016 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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