A Multiplex Device Based on Tunable Nanoshear Forces for Highly Specific Detection of Multiple Protein Biomarkers

Vaidyanathan, Ramanathan, van Leeuwen, Lara Michelle, Rauf, Sakandar, Shiddiky, Muhammad J. A and Trau, Matt (2014). A Multiplex Device Based on Tunable Nanoshear Forces for Highly Specific Detection of Multiple Protein Biomarkers. In: Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS). 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Antonio, TX United States, (1972-1974). 26-30 October 2014.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Author Vaidyanathan, Ramanathan
van Leeuwen, Lara Michelle
Rauf, Sakandar
Shiddiky, Muhammad J. A
Trau, Matt
Title of paper A Multiplex Device Based on Tunable Nanoshear Forces for Highly Specific Detection of Multiple Protein Biomarkers
Conference name 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Conference location San Antonio, TX United States
Conference dates 26-30 October 2014
Convener Stephen C. Jacobson
Proceedings title Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS)
Journal name 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Place of Publication San Antonio, TX United States
Publisher MicroTAS
Publication Year 2014
Year available 2014
Sub-type Fully published paper
ISBN 9780979806476
Start page 1972
End page 1974
Total pages 3
Language eng
Formatted Abstract/Summary
We describe a new multiplexed device for the sensitive detection of multiple protein biomarkers in serum by using an alternating current (ac) electrohydrodynamics (ac-EHD) induced surface shear forces based phenomenon referred to as nanoshearing [1,2]. The tunable nature (via manipulation of ac field) of nanoshearing forces can enhance the capture performance of the devices (i.e., enhances the number of sensor-target collisions). This can also selectively displace nonspecifically bound molecules from the electrode surface (i.e., shear forces can be tuned to shear away nonspecific species from biological fluids). To demonstrate the utility and applicability of this phenomenon, we present data on a purpose-built microfluidic device that employs nanoshearing to specifically capture protein biomarkers from complex biological fluids [3].
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Fri, 27 Feb 2015, 18:47:27 EST by Cathy Fouhy on behalf of Aust Institute for Bioengineering & Nanotechnology