Understanding the complexity and malleability of T-cell recognition

Miles, John J., McCluskey, James, Rossjohn, Jamie and Gras, Stephanie (2015) Understanding the complexity and malleability of T-cell recognition. Immunology and Cell Biology, 93 5: 433-441. doi:10.1038/icb.2014.112


Author Miles, John J.
McCluskey, James
Rossjohn, Jamie
Gras, Stephanie
Title Understanding the complexity and malleability of T-cell recognition
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 1440-1711
0818-9641
Publication date 2015-01-13
Year available 2015
Sub-type Article (original research)
DOI 10.1038/icb.2014.112
Open Access Status Not yet assessed
Volume 93
Issue 5
Start page 433
End page 441
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2403 Immunology
1307 Cell Biology
Abstract T cells are the master regulators of immune system function, continually walking the biological tightrope between adequate host defence and accidental host pathology. Tolerance is maintained or broken through an intricate structural interplay between the T-cell receptor (TCR) and major histocompatibility complex (MHC) molecule cradling peptide antigens (p). Recent advances in structural biology have shown that the TCR/pMHC interface is surprising precise and extraordinarily malleable. We have seen that seemingly minor changes in the TCR/pMHC interface can abrogate function, as well as substantial conformational changes before and after TCR docking. Our understanding of T-cell biology has also been altered with the knowledge that MHC molecules can bind not only peptides, but also an array of natural and synthetic compounds. Here, we review some examples of the precision and flexibility intrinsic to the TCR/p/MHCI axis.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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