The global burden of mental, neurological and substance use disorders: An analysis from the global burden of disease study 2010

Whiteford, Harvey A., Ferrari, Alize J., Degenhardt, Louisa, Feigin, Valery and Vos, Theo (2015) The global burden of mental, neurological and substance use disorders: An analysis from the global burden of disease study 2010. PLoS One, 10 2: 207-217. doi:10.1371/journal.pone.0116820


Author Whiteford, Harvey A.
Ferrari, Alize J.
Degenhardt, Louisa
Feigin, Valery
Vos, Theo
Title The global burden of mental, neurological and substance use disorders: An analysis from the global burden of disease study 2010
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-02-06
Year available 2015
Sub-type Article (original research)
DOI 10.1371/journal.pone.0116820
Open Access Status DOI
Volume 10
Issue 2
Start page 207
End page 217
Total pages 14
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract Background
Formatted abstract
Background
The Global Burden of Disease Study 2010 (GBD 2010), estimated that a substantial proportion of the world’s disease burden came from mental, neurological and substance use disorders. In this paper, we used GBD 2010 data to investigate time, year, region and age specific trends in burden due to mental, neurological and substance use disorders.

Method
For each disorder, prevalence data were assembled from systematic literature reviews. DisMod-MR, a Bayesian meta-regression tool, was used to model prevalence by country, region, age, sex and year. Prevalence data were combined with disability weights derived from survey data to estimate years lived with disability (YLDs). Years lost to premature mortality (YLLs) were estimated by multiplying deaths occurring as a result of a given disorder by the reference standard life expectancy at the age death occurred. Disability-adjusted life years (DALYs) were computed as the sum of YLDs and YLLs.

Results
In 2010, mental, neurological and substance use disorders accounted for 10.4% of global DALYs, 2.3% of global YLLs and, 28.5% of global YLDs, making them the leading cause of YLDs. Mental disorders accounted for the largest proportion of DALYs (56.7%), followed by neurological disorders (28.6%) and substance use disorders (14.7%). DALYs peaked in early adulthood for mental and substance use disorders but were more consistent across age for neurological disorders. Females accounted for more DALYs in all mental and neurological disorders, except for mental disorders occurring in childhood, schizophrenia, substance use disorders, Parkinson’s disease and epilepsy where males accounted for more DALYs. Overall DALYs were highest in Eastern Europe/Central Asia and lowest in East Asia/the Pacific.

Conclusion
Mental, neurological and substance use disorders contribute to a significant proportion of disease burden. Health systems can respond by implementing established, cost effective interventions, or by supporting the research necessary to develop better prevention and treatment options.
Keyword Psychiatry
Psychiatry
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 1041742
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
 
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