Raman-encoded microbeads for spectral multiplexing with SERS detection

Lai, Yuming, Sun, Shuqing, He, Tao, Schlücker, Sebastian and Wang, Yuling (2015) Raman-encoded microbeads for spectral multiplexing with SERS detection. RSC Advances, 5 18: 13762-13767. doi:10.1039/c4ra16163g

Author Lai, Yuming
Sun, Shuqing
He, Tao
Schlücker, Sebastian
Wang, Yuling
Title Raman-encoded microbeads for spectral multiplexing with SERS detection
Journal name RSC Advances   Check publisher's open access policy
ISSN 2046-2069
Publication date 2015-01-20
Year available 2015
Sub-type Article (original research)
DOI 10.1039/c4ra16163g
Open Access Status DOI
Volume 5
Issue 18
Start page 13762
End page 13767
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher RSC Publications
Language eng
Abstract Simultaneous detection of multiple molecular targets can greatly facilitate early diagnosis and drug discovery. Encoding micron-sized beads with optically active tags is one of the most popular methods to achieve multiplexing. Noble metal nanoparticle labels for optical detection by surface-enhanced Raman spectroscopy (SERS) exhibit narrow bandwidths, high photostability and intense Raman signals. In this study, we demonstrate the feasibility of spectral multiplexing by SERS using micron-sized polystyrene (PS) beads loaded with SERS-active nanoparticles. The silica-encapsulated SERS nanotags comprise gold nanocrystals with a self-assembled monolayer (SAM) of aromatic thiols as Raman reporter molecules for spectral identification. SERS microspectroscopic images of single Raman-encoded PS microbeads indicate the homogeneous spatial distribution of the SERS-active nanoparticles on the surface of the beads. By using up to five different Raman reporters, 31 spectrally distinct micron-sized beads were encoded and characterized spectroscopically at the single-bead level.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Sat, 21 Feb 2015, 17:43:22 EST by Yuling Wang on behalf of Aust Institute for Bioengineering & Nanotechnology