Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma

Tovey, Euan R., Stelzer-Braid, Sacha, Toelle, Brett G., Oliver, Brian G., Reddel, Helen K., Willenborg, Christiana M., Belessis, Yvonne, Garden, Frances L., Jaffe, Adam, Strachan, Roxanne, Eyles, Darryl, Rawlinson, William D. and Marks, Guy B. (2015) Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma. Journal of Allergy and Clinical Immunology, 135 3: 663-669.e12. doi:10.1016/j.jaci.2014.10.020

Author Tovey, Euan R.
Stelzer-Braid, Sacha
Toelle, Brett G.
Oliver, Brian G.
Reddel, Helen K.
Willenborg, Christiana M.
Belessis, Yvonne
Garden, Frances L.
Jaffe, Adam
Strachan, Roxanne
Eyles, Darryl
Rawlinson, William D.
Marks, Guy B.
Title Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2015-03-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jaci.2014.10.020
Open Access Status Not Open Access
Volume 135
Issue 3
Start page 663
End page 669.e12
Total pages 19
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
Background: Viruses are frequently associated with acute exacerbations of asthma, but the extent to which they contribute to the level of day-to-day symptom control is less clear.

Objective: We sought to explore the relationship between viral infections, host and environmental factors, and respiratory symptoms in children.

Methods: Sixty-seven asthmatic children collected samples twice weekly for an average of 10 weeks. These included nasal wash fluid and exhaled breath for PCR-based detection of viral RNA, lung function measurements, and records of medication use and asthma and respiratory symptoms in the previous 3 days. Atopy, mite allergen exposure, and vitamin D levels were also measured. Mixed-model regression analyses were performed.

Results: Human rhinoviruses (hRVs) were detected in 25.5% of 1232 nasal samples and 11.5% of breath samples. Non-hRV viruses were detected in less than 3% of samples. hRV in nasal samples was associated with asthma symptoms (cough and phlegm: odds ratio = 2.0; 95% CI = 1.4-2.86, P = .0001; wheeze and chest tightness: odds ratio = 2.34, 95% CI = 1.55-3.52, P < .0001) and with cold symptoms, as reported concurrently with sampling and 3 to 4 days later. No differences were found between the 3 hRV genotypes (hRV-A, hRV-B, and hRV-C) in symptom risk. A history of inhaled corticosteroid use, but not atopic status, mite allergen exposure, or vitamin D levels, modified the association between viruses and asthma symptoms.

Conclusion: The detection of nasal hRV was associated with a significantly increased risk of day-to-day asthma symptoms in children. Host, virus genotype, and environmental factors each had only a small or no effect on the relationship of viral infections to asthma symptoms.
Keyword Virus
Asthma control
Mixed-model analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Wed, 18 Feb 2015, 20:24:15 EST by Susan Day on behalf of Queensland Brain Institute