Antibodies to Leptospira among blood donors in higher-risk areas of Australia: possible implications for transfusion safety

Faddy, Helen, Seed, Clive, Lau, Colleen, Racloz, Vanessa, Flower, Robert, Smythe, Lee, Burns, Mary-Anne, Dohnt, Michael, Craig, Scott, Harley, Robert and Weinstein, Philip (2015) Antibodies to Leptospira among blood donors in higher-risk areas of Australia: possible implications for transfusion safety. Blood Transfusion, 13 1: 32-36. doi:10.2450/2014.0012-14


Author Faddy, Helen
Seed, Clive
Lau, Colleen
Racloz, Vanessa
Flower, Robert
Smythe, Lee
Burns, Mary-Anne
Dohnt, Michael
Craig, Scott
Harley, Robert
Weinstein, Philip
Title Antibodies to Leptospira among blood donors in higher-risk areas of Australia: possible implications for transfusion safety
Formatted title
Antibodies to Leptospira among blood donors in higher-risk areas of Australia: possible implications for transfusion safety
Journal name Blood Transfusion   Check publisher's open access policy
ISSN 1723-2007
Publication date 2015-01-01
Sub-type Article (original research)
DOI 10.2450/2014.0012-14
Open Access Status DOI
Volume 13
Issue 1
Start page 32
End page 36
Total pages 5
Place of publication Milan, Italy
Publisher SIMTI Servizi Sri
Language eng
Formatted abstract
Background. Leptospirosis is one of the most common bacterial zoonoses worldwide, and clinical manifestations range from asymptomatic infection to acute febrile illness, multi-organ failure and death. Asymptomatic, acute bacteraemia in a blood donor provides a potential for transfusion-transmission, although only a single such case from India has been recorded. Human leptospirosis is uncommon in developed countries; however, the state of Queensland in Australia has one of the highest rates among developed countries, especially after increased rainfall. This study examined the prevalence of antibodies to Leptrospira spp. in blood donors residing in higher-risk areas of Australia, to evaluate the appropriateness of current blood safety guidelines.
Materials and methods. Plasma samples collected from blood donors residing in higher-risk areas of Australia during 2009 and 2011 were included in the study. All samples were tested for the presence of antibodies to 22 leptospiral serovars using the microscopic agglutination test.
Result. No sample had antibody titres suggestive of a current or recent infection, however, seven samples (1.44% 95% CI: 0.38-2.50%) had titres suggestive of a past infection.
Discussion. This study provides data that may support the appropriateness of current relevant donor selection policies in Australia. Given that the risk profile for leptospirosis is expanding and that the infection is likely to become more prevalent with climate change, this disease may become more of a concern for transfusion safety in the future.
Keyword Emerging pathogen
Climate
Rainfall
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
Child Health Research Centre Publications
 
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