Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII

Margrie, TW, Rostas, JAP and Sah, P (1998) Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII. Nature Neuroscience, 1 5: 378-383.

Author Margrie, TW
Rostas, JAP
Sah, P
Title Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII
Journal name Nature Neuroscience   Check publisher's open access policy
ISSN 1097-6256
Publication date 1998-01-01
Sub-type Article (original research)
Volume 1
Issue 5
Start page 378
End page 383
Total pages 6
Language eng
Abstract CaMKII is a calcium-activated kinase that is abundant in neurons and has been strongly implicated in memory and learning. Here we show that low-frequency stimulation of glutamatergic afferents in hippocampal slices from juvenile domestic chicks results in long-term depression of synaptic transmission. This reduction does not require activation of NMDA or metabotropic glutamate receptors and does not require a rise in postsynaptic calcium. However, buffering presynaptic calcium prevents the reduction of the excitatory postsynaptic potential or current that is induced by low-frequency stimulation. in addition, application of the calmodulin antagonist calmidazolium, or the specific CaMKII antagonist KN-93, completely blocks long-term depression. These findings demonstrate a newsy discovered form of long-term synaptic depression in the avian hippocampus.
Keyword Neurosciences
Dependent Protein-kinase
Squid Giant Synapse
Ii Inhibitor Kn-93
Calcium Channels
Neurotransmitter Release
Interaction Site
Calmodulin
Potentiation
Fluoride
Cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 20:43:27 EST