Bioelectrical impedance analysis predicts outcome in patients with suspected bacteremia

Schwenk, A, Ward, LC, Elia, M and Scott, GM (1998) Bioelectrical impedance analysis predicts outcome in patients with suspected bacteremia. Infection, 26 5: 277-282. doi:10.1007/BF02962247


Author Schwenk, A
Ward, LC
Elia, M
Scott, GM
Title Bioelectrical impedance analysis predicts outcome in patients with suspected bacteremia
Journal name Infection   Check publisher's open access policy
ISSN 0300-8126
Publication date 1998-01-01
Year available 1998
Sub-type Article (original research)
DOI 10.1007/BF02962247
Open Access Status Not yet assessed
Volume 26
Issue 5
Start page 277
End page 282
Total pages 6
Place of publication HEIDELBERG
Publisher SPRINGER HEIDELBERG
Language eng
Subject 2726 Microbiology (medical)
2725 Infectious Diseases
Abstract Fluid shifts from intracellular to extracellular water (ICW to ECW) are a feature of sepsis, caused by increased vascular permeability and cell catabolism. Changes in ECW and total body water (TBW) were assessed in a prospective observational study of patients with bacteremia by a bedside technique, and its prognostic impact determined; In 78 hospital patients with fever, the resistance ratio (Rinf/RO) and estimated ECW/TBW ratio from multifrequency bioelectrical impedance analysis, and serum albumin concentration were measured. Rinf/RO and ECW/TBW ratios decreased from day 0 to 2 in patients with significant bacteremia (n = 31), but not in patients with doubtful or negative blood cultures (n = 22 and 25), Increased Rinf/RO at baseline, and further increase of ECW/TBW from day 0 to 2, were associated with lower rate of recovery after 1 week and with higher mortality. Baseline Rinf/RO above the median (0.75) had positive and negative predictive values of 0.31 and 0.95 for death. This prognostic effect was independent of underlying disease and blood culture result in a multivariate model. Hypoalbuminemia at baseline was predictive of outcome, but changes in albumin from day 0 to 2 were unrelated to blood culture results or outcome. In patients with bacteremia,fluid shifts from intracellular to extracellular,vater occur early are rapidly reversible by antibiotic treatment but are associated with adverse prognosis. Bioelectrical impedance deserves further study as a tool for bedside monitoring of patients with bacteremia.
Keyword Infectious Diseases
Total-body Water
Critically Ill Patients
Multiple Organs
Skeletal-muscle
Permeability
Bioimpedance
Dehydration
Infections
Mortality
Survival
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Mon, 13 Aug 2007, 20:43:18 EST