Functional non-coding RNAs derived from the flavivirus 3' untranslated region

Clarke, B. D., Roby, J. A., Slonchak, A. and Khromykh, A. A. (2015) Functional non-coding RNAs derived from the flavivirus 3' untranslated region. Virus Research, 206 53-61. doi:10.1016/j.virusres.2015.01.026

Author Clarke, B. D.
Roby, J. A.
Slonchak, A.
Khromykh, A. A.
Title Functional non-coding RNAs derived from the flavivirus 3' untranslated region
Journal name Virus Research   Check publisher's open access policy
ISSN 0168-1702
Publication date 2015-08-03
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.virusres.2015.01.026
Open Access Status Not yet assessed
Volume 206
Start page 53
End page 61
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 2406 Virology
2725 Infectious Diseases
1306 Cancer Research
Abstract Flaviviruses are single-stranded positive sense RNA enveloped viruses. The flavivirus genus includes important human pathogens such as dengue virus (DENV), West Nile virus (WNV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Murray Valley encephalitis virus (MVEV). In addition to the viral proteins and viral genomic RNA, flaviviruses produce at least two functional non-coding RNAs derived from the 3′ untranslated region (3′UTR), the subgenomic flavivirus RNA (sfRNA) and a putative WNV miRNA (KUN-miR-1). In this review we summarize published data from studies with WNV, YFV, DENV, JEV, and MVEV on sfRNA production following incomplete degradation of the viral genomic RNA by the cellular 5′–3′ exoribonuclease 1 (XRN1), RNA structural elements involved in stalling XRN1 to generate sfRNA, and functions of sfRNA in modulating cellular mRNA decay and RNAi pathways as well as in modulating anti-viral type I interferon response. In addition, we also summarize data on the mechanisms of biogenesis of 3′UTR-derived KUN-miR-1 and its function in WNV replication in mosquito host, along with recent findings on a discovery of a second potential flaviviral miRNA vsRNA5, derived from the 3′UTR of DENV. This review thus summarizes the known mechanisms of generation and the functions of flaviviral 3′UTR-derived non-coding RNAs.
Keyword Flavivirus
3′ untranslated region
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 1045080
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
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Created: Fri, 13 Feb 2015, 20:42:06 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences