In vitro evaluation of paclitaxel loaded amorphous chitin nanoparticles for colon cancer drug delivery

Smitha, K. T., Anitha, A., Furuike, T., Tamura, H., Nair, S. V. and Jayakumar, R. (2013) In vitro evaluation of paclitaxel loaded amorphous chitin nanoparticles for colon cancer drug delivery. Colloids and Surfaces B: Biointerfaces, 104 245-253. doi:10.1016/j.colsurfb.2012.11.031

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Author Smitha, K. T.
Anitha, A.
Furuike, T.
Tamura, H.
Nair, S. V.
Jayakumar, R.
Title In vitro evaluation of paclitaxel loaded amorphous chitin nanoparticles for colon cancer drug delivery
Journal name Colloids and Surfaces B: Biointerfaces   Check publisher's open access policy
ISSN 0927-7765
1873-4367
Publication date 2013-04-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.colsurfb.2012.11.031
Open Access Status File (Author Post-print)
Volume 104
Start page 245
End page 253
Total pages 9
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
Chitin and its derivatives have been widely used in drug delivery applications due to its biocompatible, biodegradable and non-toxic nature. In this study, we have developed amorphous chitin nanoparticles (150 ± 50 nm) and evaluated its potential as a drug delivery system. Paclitaxel (PTX), a major chemotherapeutic agent was loaded into amorphous chitin nanoparticles (AC NPs) through ionic cross-linking reaction using TPP. The prepared PTX loaded AC NPs had an average diameter of 200 ± 50 nm. Physico-chemical characterization of the prepared nanoparticles was carried out. These nanoparticles were proven to be hemocompatible and in vitro drug release studies showed a sustained release of PTX. Cellular internalization of the NPs was confirmed by fluorescent microscopy as well as by flow cytometry. Anticancer activity studies proved the toxicity of PTX-AC NPs toward colon cancer cells. These preliminary results indicate the potential of PTX-AC NPs in colon cancer drug delivery.
Keyword Nanoparticles
Colon cancer
Drug delivery
Amorphous chitin
Paclitaxel
Ionic cross linking
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 12 Feb 2015, 22:17:55 EST by Anitha Sudheesh Kumar on behalf of School of Chemistry & Molecular Biosciences