The evidence for functional non-CpG methylation in mammalian cells

Patil, Vibha, Ward, Robyn L. and Hesson, Luke B. (2014) The evidence for functional non-CpG methylation in mammalian cells. Epigenetics, 9 6: 823-828. doi:10.4161/epi.28741


Author Patil, Vibha
Ward, Robyn L.
Hesson, Luke B.
Title The evidence for functional non-CpG methylation in mammalian cells
Journal name Epigenetics   Check publisher's open access policy
ISSN 1559-2308
1559-2294
Publication date 2014-04-09
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4161/epi.28741
Open Access Status Not Open Access
Volume 9
Issue 6
Start page 823
End page 828
Total pages 6
Place of publication New York, NY United States
Publisher Taylor & Francis
Language eng
Abstract In mammalian genomes, the methylation of cytosine residues within CpG dinucleotides is crucial to normal development and cell differentiation. However, methylation of cytosines in the contexts of CpA, CpT, and CpC (non-CpG methylation) has been reported for decades, yet remains poorly understood. In recent years, whole genome bisulphite sequencing (WGBS) has confirmed significant levels of non-CpG methylation in specific tissues and cell types. Non-CpG methylation has several properties that distinguish it from CpG methylation. Here we review the literature describing non-CpG methylation in mammalian cells, describe the important characteristics that distinguish it from CpG methylation, and discuss its functional importance.
Keyword DNA methylation
Non-CpG methylation
Non-CG methylation
Epigenetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
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