Randomized trial of a decision aid for individuals considering genetic testing for hereditary nonpolyposis colorectal cancer risk

Wakefield, Claire E., Meiser, Bettina, Homewood, Judi, Ward, Robyn, O'Donnell, Sheridan and Kirk, Judy (2008) Randomized trial of a decision aid for individuals considering genetic testing for hereditary nonpolyposis colorectal cancer risk. Cancer, 113 5: 956-965. doi:10.1002/cncr.23681


Author Wakefield, Claire E.
Meiser, Bettina
Homewood, Judi
Ward, Robyn
O'Donnell, Sheridan
Kirk, Judy
Title Randomized trial of a decision aid for individuals considering genetic testing for hereditary nonpolyposis colorectal cancer risk
Journal name Cancer   Check publisher's open access policy
ISSN 0008-543X
Publication date 2008-09-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/cncr.23681
Open Access Status DOI
Volume 113
Issue 5
Start page 956
End page 965
Total pages 10
Publisher JOHN WILEY & SONS INC
Language eng
Subject 1306 Cancer Research
2730 Oncology
Abstract BACKGROUND. Despite the potential benefits of genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC) risk, individuals can find the genetic testing decision-making process complicated and challenging. The goal of the current study was to measure the effectiveness of a tailored decision aid designed specifically to assist individuals to make informed decisions regarding genetic testing for HNPCC risk. METHODS. In all, 153 individuals were randomized to receive the decision aid or a control pamphlet at the end of their first genetic counseling consultation. Of these, 109 (71.2%) completed the first questionnaire 1 week after consultation, whereas 95 (62.1%) completed the 6-month follow-up questionnaire. RESULTS. Although the decision aid had no significant effect on postdecisional regret or actual genetic testing decision, the trial results demonstrated that participants who received the decision aid had significantly lower levels of decisional conflict (ie, uncertainty) regarding genetic testing (chi-square(1) = 8.97; P = .003) and were more likely to be classified as having made an informed choice concerning genetic testing (chi-square(1) = 4.37; P = .037) than participants who received a control pamphlet. Also, men who received the decision aid had significantly higher knowledge levels regarding genetic testing compared with men who received the control pamphlet, whereas no such differences were found for women (chi-square(2) = 6.76; P = .034). CONCLUSIONS. A decision aid for individuals considering genetic testing for HNPCC is an effective intervention to reduce uncertainty and assist individuals to make an informed choice regarding genetic testing for HNPCC after genetic counseling.
Keyword Decision aid
Genetic testing
Hereditary nonpolyposis colorectal cancer
Patient education
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 300441
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Wed, 11 Feb 2015, 20:41:07 EST by Ms Kate Rowe