Does MSI-low exist?

Tomlinson, Ian, Halford, Sarah, Aaltonen, Lauri, Hawkins, Nicholas and Ward, Robyn (2002) Does MSI-low exist?. Journal of Pathology, 197 1: 6-13. doi:10.1002/path.1071

Author Tomlinson, Ian
Halford, Sarah
Aaltonen, Lauri
Hawkins, Nicholas
Ward, Robyn
Title Does MSI-low exist?
Journal name Journal of Pathology   Check publisher's open access policy
ISSN 0022-3417
Publication date 2002-05-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/path.1071
Open Access Status Not yet assessed
Volume 197
Issue 1
Start page 6
End page 13
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract Microsatellite instability is a well-recognised phenomenon. Ten to 15% of sporadic colorectal cancers with a high level of MSI form a well defined group with distinct clinicopathological features. The set of tumours with low level of microsatellite instability (MSI-low), though widely referred to, is not a clearly defined group. The definitions of MSI-low have varied among groups and between different studies from the same group. Some studies have found associations between the MSI-L phenotype and molecular features, notably a higher frequency of K-ras mutations, and, possibly, methylation of methylguanine methyltransferase. Two recent independent studies, however, showed respectively that 68% and 79%, non-MSI-H cancers showed some MSI and could therefore be classed nominally as MSI-L. There was no evidence for a qualitatively discrete MSI-L group, but quantitative differences in the level of MSI were found.
Keyword Colorectal cancer
Microsatellite instability
Microsatellite stable
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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