Co-blockade of immune checkpoints and adenosine A(2A) receptor suppresses metastasis

Young, Arabella, Mittal, Deepak, Stannard, Kimberley, Yong, Michelle, Teng, Michele W. L., Allard, Bertrand, Stagg, John and Smyth, Mark J. (2014) Co-blockade of immune checkpoints and adenosine A(2A) receptor suppresses metastasis. Oncoimmunology, 3 10: e958952-1-e958952-3. doi:10.4161/21624011.2014.958952

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Author Young, Arabella
Mittal, Deepak
Stannard, Kimberley
Yong, Michelle
Teng, Michele W. L.
Allard, Bertrand
Stagg, John
Smyth, Mark J.
Title Co-blockade of immune checkpoints and adenosine A(2A) receptor suppresses metastasis
Formatted title
Co-blockade of immune checkpoints and adenosine A2A receptor suppresses metastasis
Journal name Oncoimmunology   Check publisher's open access policy
ISSN 2162-4011
2162-402X
Publication date 2014-11-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4161/21624011.2014.958952
Volume 3
Issue 10
Start page e958952-1
End page e958952-3
Total pages 3
Place of publication Austin, TX United States
Publisher Landes Bioscience
Language eng
Formatted abstract
Immunosuppressive pathways active within the tumor microenvironment must be targeted in combination to sufficiently bolster antitumor immune defenses. Inhibition of A2A adenosine receptor signaling in combination with immune checkpoint blockade enhances CD8+ T and NK cell anti-metastatic activity. This results in reduced metastatic burden and improved survival in pre-clinical models.
Keyword Adenosine
Combination therapy
Immune checkpoint
Metastasis
PD-1
Tumor-mediated immunosuppression
Anti-PD-1
Antibody
Melanoma
Cancer
Tumors
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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