Glycemic status and predictors of relapse for diabetic cats in remission

Gottlieb, S., Rand, J. S., Marshall, R. and Morton, J. (2015) Glycemic status and predictors of relapse for diabetic cats in remission. Journal of Veterinary Internal Medicine, 29 1: 184-192. doi:10.1111/jvim.12509

Author Gottlieb, S.
Rand, J. S.
Marshall, R.
Morton, J.
Title Glycemic status and predictors of relapse for diabetic cats in remission
Journal name Journal of Veterinary Internal Medicine   Check publisher's open access policy
ISSN 1939-1676
Publication date 2015-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1111/jvim.12509
Open Access Status DOI
Volume 29
Issue 1
Start page 184
End page 192
Total pages 9
Place of publication Hoboken NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract

It is unknown if diabetic cats in remission have persistent abnormalities of glucose metabolism and should be considered prediabetic, or have normal glucose tolerance.


To characterize glycemic status of diabetic cats in remission and to determine predictors of relapse.


A total of 21 cats in diabetic remission and 28 healthy control cats.


At a median of 107 days after remission, screening blood glucose concentration was measured on entry to the clinic. After a 24-hour fast in hospital, fasting blood glucose, fructosamine and feline pancreatic lipase concentrations were measured, and 3 hours later, a simplified IV glucose tolerance test (1 g glucose/kg) performed. Twenty cats were monitored for relapse for at least 9 months.


Of the 21 cats in remission, 19% (4/21) had impaired fasting glucose concentration and 76% (16/21) had impaired glucose tolerance. Of cats followed up for 9 months after testing, 30% (6/20) had relapsed and required insulin treatment. Fasting blood glucose concentration ≥7.5 mmol/L (≥135 mg/dL) (odds ratio [OR] = 12.8) and severely impaired glucose tolerance (≥5 hours to return to <6.5 mmol/L or <117 mg/dL; OR = 15.2) were significantly associated with relapse. Blood glucose concentration >14 mmol/L; 252 mg/dL at 3 hours was significantly associated with relapse (OR = 10.1).

Conclusion and Clinical Importance

Most cats in diabetic remission have impaired glucose tolerance and a minority have impaired fasting glucose concentration and should be considered prediabetic. More severe glucose intolerance and impaired fasting glucose concentration are predictors of relapse. Ongoing glucose monitoring of diabetic cats in remission is recommended.
Keyword Diabetes mellitus
Glucose tolerance test
Impaired fasting glucose concentration
Impaired glucose tolerance
Screening glucose
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 24 Nov 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Veterinary Science Publications
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