Rising incidence of early-onset colorectal cancer in Australia over two decades: report and review

Young, Joanne P., Win, Aung Ko, Rosty, Christophe, Flight, Ingrid, Roder, David, Young, Graeme P., Frank, Oliver, Suthers, Graeme K., Hewett, Peter J., Ruszkiewicz, Andrew, Hauben, Ehud, Adelstein, Barbara-Ann, Parry, Susan, Townsend, Amanda, Hardingham, Jennifer E. and Price, Timothy J. (2015) Rising incidence of early-onset colorectal cancer in Australia over two decades: report and review. Journal of Gastroenterology and Hepatology, 30 1: 6-13. doi:10.1111/jgh.12792

Author Young, Joanne P.
Win, Aung Ko
Rosty, Christophe
Flight, Ingrid
Roder, David
Young, Graeme P.
Frank, Oliver
Suthers, Graeme K.
Hewett, Peter J.
Ruszkiewicz, Andrew
Hauben, Ehud
Adelstein, Barbara-Ann
Parry, Susan
Townsend, Amanda
Hardingham, Jennifer E.
Price, Timothy J.
Title Rising incidence of early-onset colorectal cancer in Australia over two decades: report and review
Journal name Journal of Gastroenterology and Hepatology   Check publisher's open access policy
ISSN 1440-1746
Publication date 2015-01-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/jgh.12792
Open Access Status DOI
Volume 30
Issue 1
Start page 6
End page 13
Total pages 8
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
The average age at diagnosis for colorectal cancer (CRC) in Australia is 69, and the age-specific incidence rises rapidly after age 50 years. The incidence has stabilized or is declining in older age groups in Australia during recent decades, possibly related to the increased uptake of screening and high-risk surveillance. In the same time frame, a rising incidence of CRC in younger adults has been well-documented in the United States. This rise in incidence in the young has not been reported from other countries that share long-term exposure to westernised urban lifestyles. Using data from the Australian Institute of Health and Welfare, we examined trends in national incidence rates for CRC under age 50 years and observed that rates in people under age 40 years have been rising for the last two decades. We further performed a review of the literature regarding CRC in young adults to outline the extent of current understanding, explore potential risk factors such as obesity, alcohol, and sedentary lifestyles, and to identify the questions remaining to be addressed. Although absolute numbers might not justify a population screening approach, the dispersal of young adults with CRC across the primary health-care system decreases probability of their recognition. Patient and physician awareness, aided by stool and emerging blood-screening tests and risk profiling tools, have the potential to aid in identification of those young adults who would most benefit from a colonoscopy through early detection of CRCs or by removal of advanced polyps.
Keyword Early-onset colorectal cancer
Risk factors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 23 Dec 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
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