Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala

Mahanty, Nishith K. and Sah, Pankaj (1998) Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala. Nature, 394 6694: 683-687. doi:10.1038/29312


Author Mahanty, Nishith K.
Sah, Pankaj
Title Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 1998-01-01
Sub-type Article (original research)
DOI 10.1038/29312
Volume 394
Issue 6694
Start page 683
End page 687
Total pages 5
Place of publication London
Publisher Nature Publishing Group
Language eng
Abstract Fear conditioning is a paradigm that has been used as a model for emotional learning in animals'. The cellular correlate of fear conditioning is thought to be associative N-methyl-D-aspartate (NMDA) receptor-dependent synaptic plasticity within the amygdala(1-3). Here we show that glutamatergic synaptic transmission to inhibitory interneurons in the basolateral amygdala is mediated solely by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. In contrast to AMPA receptors at inputs to pyramidal neurons, these receptors have an inwardly rectifying current-voltage relationship, indicative of a high permeability to calcium(4 5), Tetanic stimulation of inputs to interneurons caused an immediate and sustained increase in the efficacy of these synapses. This potentiation required a rise in postsynaptic calcium, but was independent of NMDA receptor activation. The potentiation of excitatory inputs to interneurons was reflected as an increase in the amplitude of the GABAA-mediated inhibitory synaptic current in pyramidal neurons. These results demonstrate that excitatory synapses onto interneurons within a fear conditioning circuit show NMDA-receptor independent long-term potentiation. This plasticity might underlie the increased synchronization of activity between neurons in the basolateral amygdala after fear conditioning(6).
Keyword Neurosciences
Rat Basolateral Amygdala
Neocortical Neurons
Ca2+ Permeability
B Subunit
Channels
Localization
Transmission
Hippocampus
Expression
Recordings
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 20:34:32 EST