Response of the nitrergic system to activation of the neuroendocrine stress axis

Chen, Hsiao-Jou Cortina, Spiers, Jereme G., Sernia, Conrad and Lavidis, Nickolas A. (2015) Response of the nitrergic system to activation of the neuroendocrine stress axis. Frontiers in Neuroscience, 9 Article 3: . doi:10.3389/fnins.2015.00003


Author Chen, Hsiao-Jou Cortina
Spiers, Jereme G.
Sernia, Conrad
Lavidis, Nickolas A.
Title Response of the nitrergic system to activation of the neuroendocrine stress axis
Journal name Frontiers in Neuroscience   Check publisher's open access policy
ISSN 1662-4548
1662-453X
Publication date 2015-01-21
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fnins.2015.00003
Open Access Status DOI
Volume 9
Issue Article 3
Total pages 7
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2015
Language eng
Formatted abstract
Exposure to stressful stimuli causes activation of the hypothalamic-pituitary-adrenal axis which rapidly releases high concentrations of glucocorticoid stress hormones, resulting in increased cellular metabolism and spontaneous oxygen and nitrogen radical formation. High concentrations of nitrogen radicals, including nitric oxide, cause damage to cellular proteins in addition to inhibiting components of the mitochondrial transport chain, leading to cellular energy deficiency. During stress exposure, pharmacological inhibition of nitric oxide production reduces indicators of anxiety- and depressive-like behavior in animal models. Therefore, the purpose of this review is to present an overview of the current literature on stress-evoked changes in the nitrergic system, particularly within neural tissue.
Keyword Hypothalamic pituitary adrenal axis
Glucocorticoids
Nitrergic system
Nitric oxide
Peroxynitrite
Reactive nitrogen species
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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Created: Fri, 30 Jan 2015, 02:11:35 EST by Cortina Chen on behalf of School of Biomedical Sciences