Role of ionotropic glutamate receptors in neurodegenerative and other disorders

Ragnarsson, Lotten, Dodd, Peter R. and Hynd, Matthew R. (2014). Role of ionotropic glutamate receptors in neurodegenerative and other disorders. In Handbook of neurotoxicity (pp. 1039-1070) New York, NY, United States: Springer Science+Business Media. doi:10.1007/978-1-4614-5836-4_144


Author Ragnarsson, Lotten
Dodd, Peter R.
Hynd, Matthew R.
Title of chapter Role of ionotropic glutamate receptors in neurodegenerative and other disorders
Title of book Handbook of neurotoxicity
Place of Publication New York, NY, United States
Publisher Springer Science+Business Media
Publication Year 2014
Sub-type Chapter in reference work, encyclopaedia, manual or handbook
DOI 10.1007/978-1-4614-5836-4_144
ISBN 9781461458357
9781461458364
Volume number 2
Start page 1039
End page 1070
Total pages 32
Language eng
Abstract/Summary Disorders of the central nervous system (CNS) are amongst the most complex disease states and lead to some of the most devastating conditions found in medicine today. It is well established that both genetic and epigenetic factors influence the pathogenesis of neurodegenerative disorders. More recently a growing body of evidence suggests that changes in neurotransmitter systems may underlie the pathogenic mechanisms of neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. Excitatory amino acids (EAA) are known to play key roles in neurotransmission, neuromodulation, and neurotoxicity. EAA receptors are classified into two major subdivisions, ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). L-Glu-gated ion channels, more commonly known as (iGluRs), are the primary mediators of fast excitatory synaptic transmission between neurons in the mammalian CNS. Evidence suggests that the iGluR receptor systems are involved in a number of pathophysiology conditions. This chapter will detail the current state of knowledge regarding the involvement of iGluRs in neurodegenerative and other disorders.
Keyword Alzheimer’s disease
Excitotoxicity
Ionotropic glutamate receptor
Neurodegeneration
Parkinson’s disease
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 28 Jan 2015, 23:36:51 EST by Lotten Ragnarsson-mcgrath on behalf of Institute for Molecular Bioscience