Non-invasive assessment of muscle stiffness in patients with duchenne muscular dystrophy

Lacourpaille, Lilian, Hug, Francois, Guevel, Arnaud, Pereon, Yann, Magot, Armelle, Hogrel, Jean-Yves and Nordez, Antoine (2015) Non-invasive assessment of muscle stiffness in patients with duchenne muscular dystrophy. Muscle and Nerve, 51 2: 284-286. doi:10.1002/mus.24445

Author Lacourpaille, Lilian
Hug, Francois
Guevel, Arnaud
Pereon, Yann
Magot, Armelle
Hogrel, Jean-Yves
Nordez, Antoine
Title Non-invasive assessment of muscle stiffness in patients with duchenne muscular dystrophy
Journal name Muscle and Nerve   Check publisher's open access policy
ISSN 1097-4598
Publication date 2015-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.1002/mus.24445
Open Access Status Not yet assessed
Volume 51
Issue 2
Start page 284
End page 286
Total pages 3
Place of publication Hoboken NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Introduction: Assessment of muscle mechanical properties may provide clinically valuable information for follow-up of patients with Duchenne muscular dystrophy (DMD) through the course of their disease. In this study we aimed to assess the effect of DMD on stiffness of relaxed muscles using elastography (supersonic shear imaging). Methods: Fourteen DMD patients and 13 control subjects were studied. Six muscles were measured at 2 muscle lengths (shortened and stretched): gastrocnemius medialis (GM); tibialis anterior (TA); vastus lateralis (VL); biceps brachii (BB); triceps brachii (TB); and abductor digiti minimi (ADM). Results: Stiffness was significantly higher in DMD patients compared with controls for all the muscles (main effect for population, P < 0.033 in all cases), except for ADM. The effect size was small (d = 0.33 for ADM at both muscle lengths) to large (d = 0.86 for BB/stretched). Conclusions: Supersonic shear imaging is a sensitive non-invasive technique to assess the increase in muscle stiffness associated with DMD.
Keyword Elastography
Shear elastic modulus
Supersonic shear imaging
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 23 Dec 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Health and Rehabilitation Sciences Publications
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