Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers

Santhakumar, Abishek Bommannan, Kundur, Avinash Reddy, Fanning, Kent, Netzel, Michael, Stanley, Roger and Singh, Indu (2015) Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. Journal of Functional Foods, 12 11-22. doi:10.1016/j.jff.2014.10.026


Author Santhakumar, Abishek Bommannan
Kundur, Avinash Reddy
Fanning, Kent
Netzel, Michael
Stanley, Roger
Singh, Indu
Title Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers
Journal name Journal of Functional Foods   Check publisher's open access policy
ISSN 1756-4646
2214-9414
Publication date 2015-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jff.2014.10.026
Open Access Status Not yet assessed
Volume 12
Start page 11
End page 22
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 1106 Food Science
2701 Medicine (miscellaneous)
2916 Nutrition and Dietetics
Abstract The anti-thrombotic properties of an anthocyanin-rich Queen Garnet plum juice (QGPJ) and anthocyanin-free prune juice (PJ) were studied in this randomised, double-blind, crossover trial. Twenty-one healthy subjects (M = 10, F = 11) consumed QGPJ, PJ or placebo, 200 mL/day for 28-days followed by a 2-week wash-out period. Only QGPJ supplementation inhibited platelet aggregation induced by ADP (<5%, P = 0.02), collagen (<2.7%, P < 0.001) and arachidonic acid (<4%, P < 0.001); reduced platelet activation-dependent surface-marker P-selectin expression of activated de-granulated platelets (<17.2%, P = 0.04); prolonged activated-partial thromboplastin clotting time (>2.1 s, P = 0.03); reduced plasma-fibrinogen (<7.5%, P = 0.02) and malondialdehyde levels, a plasma biomarker of oxidative stress (P = 0.016). PJ supplementation increased plasma hippuric acid content (P = 0.018). QGPJ or PJ supplementation did not affect blood cell counts, lipid profile, or inflammation markers. Our findings suggest that QGPJ but not PJ has the potential to significantly attenuate thrombosis by reducing platelet activation/hyper-coagulability and oxidative stress.
Keyword Anthocyanins
Queen-Garnet plum
Platelet activity
Thrombosis
Anti-platelet therapy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 19 Nov 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Centre for Nutrition and Food Sciences Publications
 
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