Re-purposing bridging flocculation for on-site, rapid, qualitative DNA detection in resource-poor settings

Wee, E. J. H., Lau, H. Y., Botella, J. and Trau, M. (2015) Re-purposing bridging flocculation for on-site, rapid, qualitative DNA detection in resource-poor settings. Chemical Communications, 51 27: 5828-5831. doi:10.1039/C4CC10068A


 
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Author Wee, E. J. H.
Lau, H. Y.
Botella, J.
Trau, M.
Title Re-purposing bridging flocculation for on-site, rapid, qualitative DNA detection in resource-poor settings
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1359-7345
1364-548X
Publication date 2015-01-16
Sub-type Article (original research)
DOI 10.1039/C4CC10068A
Volume 51
Issue 27
Start page 5828
End page 5831
Total pages 4
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Language eng
Abstract Developing molecular diagnostics in resource-poor settings is challenging. As such, we purpose-built a novel bridging flocculation assay for qualitative evaluation of isothermally amplified DNA by naked eye. The flocculation assay was dependent on pH, DNA polymer amounts and lengths. The method was first applied to the rapid and sensitive detection of important plant pathogens and subsequently extended to other pathogens across the animal kingdom to demonstrate the wide applications of our approach.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 20 Jan 2015, 03:42:35 EST by Eugene Wee on behalf of Aust Institute for Bioengineering & Nanotechnology