NFIX regulates proliferation and migration within the murine SVZ neurogenic niche

Heng, Yee Hsieh Evelyn, Zhou, Bo, Harris, Lachlan, Harvey, Tracey, Smith, Aaron, Horne, Elise, Martynoga, Ben, Andersen, Jimena, Achimastou, Angeliki, Cato, Kathleen, Richards, Linda J., Gronostajski, Richard M., Yeo, Giles S., Guillemot, François, Bailey, Timothy L. and Piper, Michael (2015) NFIX regulates proliferation and migration within the murine SVZ neurogenic niche. Cerebral Cortex, 25 10: 3758-3778. doi:10.1093/cercor/bhu253

Author Heng, Yee Hsieh Evelyn
Zhou, Bo
Harris, Lachlan
Harvey, Tracey
Smith, Aaron
Horne, Elise
Martynoga, Ben
Andersen, Jimena
Achimastou, Angeliki
Cato, Kathleen
Richards, Linda J.
Gronostajski, Richard M.
Yeo, Giles S.
Guillemot, François
Bailey, Timothy L.
Piper, Michael
Title NFIX regulates proliferation and migration within the murine SVZ neurogenic niche
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1047-3211
Publication date 2015-10-01
Year available 2014
Sub-type Article (original research)
DOI 10.1093/cercor/bhu253
Open Access Status Not Open Access
Volume 25
Issue 10
Start page 3758
End page 3778
Total pages 21
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Abstract Transcription factors of the nuclear factor one (NFI) family play a pivotal role in the development of the nervous system. One member, NFIX, regulates the development of the neocortex, hippocampus, and cerebellum. Postnatal Nfix−/− mice also display abnormalities within the subventricular zone (SVZ) lining the lateral ventricles, a region of the brain comprising a neurogenic niche that provides ongoing neurogenesis throughout life. Specifically, Nfix−/− mice exhibit more PAX6 expressing progenitor cells within the SVZ. However, the mechanism underlying the development of this phenotype remains undefined. Here, we reveal that NFIX contributes to multiple facets of SVZ development. Postnatal Nfix−/− mice exhibit increased levels of proliferation within the SVZ, both in vivo and in vitro as assessed by a neurosphere assay. Furthermore, we show that the migration of SVZ-derived neuroblasts to the olfactory bulb is impaired, and that the olfactory bulbs of postnatal Nfix−/− mice are smaller. We also demonstrate that gliogenesis within the rostral migratory stream is delayed in the absence of Nfix, and reveal that Gdnf (glial-derived neurotrophic factor), a known attractant for SVZ-derived neuroblasts, is a target for transcriptional activation by NFIX. Collectively, these findings suggest that NFIX regulates both proliferation and migration during the development of the SVZ neurogenic niche.
Keyword Neuroblast
Nuclear factor one X
Olfactory bulb
Rostral migratory stream
Subventricular zone
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 1003462
Institutional Status UQ
Additional Notes First published online: 19 October 2014.

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Created: Thu, 15 Jan 2015, 06:37:14 EST by Dr Michael Piper on behalf of School of Biomedical Sciences