Production of industrially-relevant isoprenoid compounds in engineered microbes

Vickers, Claudia E., Behrendorff, James B. Y. H., Bongers, Mareike, Brennan, Timothy C. R., Bruschi, Michele and Nielsen, Lars K. (2015). Production of industrially-relevant isoprenoid compounds in engineered microbes. In Birgit Kamm (Ed.), Microorganisms in biorefineries (pp. 303-334) Berlin, Heidelberg: Springer. doi:10.1007/978-3-662-45209-7_11

Author Vickers, Claudia E.
Behrendorff, James B. Y. H.
Bongers, Mareike
Brennan, Timothy C. R.
Bruschi, Michele
Nielsen, Lars K.
Title of chapter Production of industrially-relevant isoprenoid compounds in engineered microbes
Title of book Microorganisms in biorefineries
Place of Publication Berlin, Heidelberg
Publisher Springer
Publication Year 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/978-3-662-45209-7_11
Series Microbiology Monographs
ISBN 9783662452080
ISSN 1862-5576
Editor Birgit Kamm
Volume number 26
Chapter number 11
Start page 303
End page 334
Total pages 32
Total chapters 12
Language eng
Abstract/Summary Isoprenoids are the largest class of natural compounds and have extremely diverse chemical and functional properties. They are involved in many different cellular processes, including hormonal regulation, signalling, pest/pathogen defence and redox status. They also provide many of the colours, flavours and aromas found in biology. The diversity of isoprenoids lends them to a wide variety of biotechnological applications, both by exploiting their myriad natural functions and by using them as industrial chemicals/chemical feedstocks. These applications range from fine chemicals (pharmaceuticals, nutraceuticals, antimicrobials) through mid-volume (flavours, fragrances, colourants, fuel additives) and bulk (fuels, synthetic polymers, agricultural chemicals, etc.) products. However, in their natural context, individual isoprenoids are not usually found at sufficient abundance for industrial use. Moreover, extraction and/or purification may be difficult and/or expensive, or production may be highly variable, making industrial production processes challenging or impossible. Artificial synthesis is often not possible due to complexity, expense or other chemical properties/requirements. Consequently, there is a strong movement towards bioengineering of microbes for production of these valuable compounds in controlled fermentation conditions. Here we consider the requirements for developing economically viable isoprenoid production bioprocesses as well as the current state of the art in engineering production in microbes. We also discuss some of the challenges we face in bringing these technologies to the market.
Keyword Microbiology
Green Energy
Applied microbiology
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Wed, 14 Jan 2015, 06:51:27 EST by Dr Claudia Vickers on behalf of School of Chemistry & Molecular Biosciences