A candidate single nucleotide polymorphism in the 3' untranslated region of stearoyl-CoA desaturase gene for fatness quality and the gene expression in Berkshire pigs

Lim, Kyu-Sang, Kim, Jun-Mo, Lee, Eun-A, Choe, Jee-Hwan and Hong, Ki-Chang (2015) A candidate single nucleotide polymorphism in the 3' untranslated region of stearoyl-CoA desaturase gene for fatness quality and the gene expression in Berkshire pigs. Asian-Australasian Journal of Animal Sciences, 28 2: 151-157. doi:10.5713/ajas.14.0529


Author Lim, Kyu-Sang
Kim, Jun-Mo
Lee, Eun-A
Choe, Jee-Hwan
Hong, Ki-Chang
Title A candidate single nucleotide polymorphism in the 3' untranslated region of stearoyl-CoA desaturase gene for fatness quality and the gene expression in Berkshire pigs
Journal name Asian-Australasian Journal of Animal Sciences   Check publisher's open access policy
ISSN 1976-5517
1011-2367
Publication date 2015-02-01
Year available 2015
Sub-type Article (original research)
DOI 10.5713/ajas.14.0529
Open Access Status DOI
Volume 28
Issue 2
Start page 151
End page 157
Total pages 7
Place of publication Seoul, Korea, Republic of
Publisher Asian-Australasian Association of Animal Production Societies
Language eng
Formatted abstract
Fatness qualities in pigs measured by the amount of fat deposition and composition of fatty acids (FAs) in pork have considerable effect on current breeding goals. The stearoyl-CoA desaturase (SCD) gene plays a crucial role in the conversion of saturated FAs into monounsaturated FAs (MUFAs), and hence, is among the candidate genes responsible for pig fatness traits. Here, we identified a single nucleotide polymorphism (SNP, c.*2041T>C) in the 3′ untranslated region by direct sequencing focused on coding and regulatory regions of porcine SCD. According to the association analysis using a hundred of Berkshire pigs, the SNP was significantly associated with FA composition (MUFAs and polyunsaturated FAs [PUFAs]), polyunsaturated to saturated (P:S) FA ratio, n-6:n-3 FA ratio, and extent of fat deposition such as intramuscular fat and marbling (p<0.05). In addition, the SNP showed a significant effect on the SCD mRNA expression levels (p = 0.041). Based on our results, we suggest that the SCD c.*2041T>C SNP plays a role in the gene regulation and affects the fatness qualities in Berkshire pigs.
Keyword Stearoyl-CoA desaturase [SCD]
Polymorphism
Gene expression
Fatness quality
Berkshire
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Centre for Nutrition and Food Sciences Publications
 
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