Role of oral factor Xa inhibitors after acute coronary syndrome

Sharma, Abhishek, Garg, Akash, Borer, Jeffrey S., Krishnamoorthy, Parasuram, Garg, Jalaj, Lavie, Carl J., Arbab-Zadeh, Armin, Mukherjee, Debabrata, Ahmad, Hasan and Lichstein, Edgar (2014) Role of oral factor Xa inhibitors after acute coronary syndrome. Cardiology (Switzerland), 129 4: 224-232. doi:10.1159/000368747


Author Sharma, Abhishek
Garg, Akash
Borer, Jeffrey S.
Krishnamoorthy, Parasuram
Garg, Jalaj
Lavie, Carl J.
Arbab-Zadeh, Armin
Mukherjee, Debabrata
Ahmad, Hasan
Lichstein, Edgar
Title Role of oral factor Xa inhibitors after acute coronary syndrome
Journal name Cardiology (Switzerland)   Check publisher's open access policy
ISSN 1421-9751
0008-6312
Publication date 2014-11-07
Year available 2014
Sub-type Article (original research)
DOI 10.1159/000368747
Open Access Status Not Open Access
Volume 129
Issue 4
Start page 224
End page 232
Total pages 9
Place of publication Basel Switzerland
Publisher S. Karger AG
Language eng
Abstract Despite an early invasive strategy and the use of dual antiplatelet therapy, patients with acute coronary syndrome (ACS) continue to be at substantial risk for recurrent ischemic events. It is believed that this risk is, at least in part, due to an intrinsic coagulation pathway that remains activated for a prolonged period after ACS. Earlier studies using warfarin showed a reduction in ischemic events, but the overall benefits were offset by increased bleeding complications. Recently, there has been increased interest in the potential role of new oral anticoagulants, some of which target factor Xa, after ACS. Factor Xa is important for the coagulation pathway and also plays a role in cellular proliferation and inflammation. It may thus be an attractive target for therapeutic intervention in ACS. Recently, various oral factor Xa inhibitors have been studied as potential treatment options for ACS. This review will focus on currently available data to evaluate the possible role of factor Xa inhibitors in the management of patients with ACS.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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