Dragmacidins: New protein phosphatase inhibitors from a southern Australian deep-water marine sponge, Spongosorites sp.

Capon, Robert J., Rooney, Francis, Murray, Leanne M., Collins, Elizabeth, Sim, Alistair T. R., Rostas, John A. P., Butler, Mark S. and Carroll, Anthony R. (1998) Dragmacidins: New protein phosphatase inhibitors from a southern Australian deep-water marine sponge, Spongosorites sp.. Journal of Natural Products, 61 5: 660-662. doi:10.1021/np970483t


Author Capon, Robert J.
Rooney, Francis
Murray, Leanne M.
Collins, Elizabeth
Sim, Alistair T. R.
Rostas, John A. P.
Butler, Mark S.
Carroll, Anthony R.
Title Dragmacidins: New protein phosphatase inhibitors from a southern Australian deep-water marine sponge, Spongosorites sp.
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
Publication date 1998-01-01
Year available 1998
Sub-type Article (original research)
DOI 10.1021/np970483t
Open Access Status Not yet assessed
Volume 61
Issue 5
Start page 660
End page 662
Total pages 3
Place of publication Cincinnati, Ohio
Publisher American Chemical Society
Language eng
Subject 06 Biological Sciences
Abstract A Spongosorites sp. collected during trawling operations off the southern coast of Australia returned the new alkaloid dragmacidin E (3), the structure of which was secured by detailed spectroscopic analysis. Dragmacidin E (3), and its co-metabolite dragmacidin D (1) have been identified as potent inhibitors of serine-threonine protein phosphatases.
Keyword Plant Sciences
Chemistry, Applied
Chemistry, Medicinal
Pharmacology & Pharmacy
Bis-indole Alkaloids
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 118 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 130 times in Scopus Article | Citations
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Created: Mon, 13 Aug 2007, 20:28:34 EST