Construction of a hypervirulent and specific mycoinsecticide for locust control

Fang, Weiguo, Lu, Hsiao-Ling, King, Glenn F and St. Leger, Raymond J. (2014) Construction of a hypervirulent and specific mycoinsecticide for locust control. Scientific Reports, 4 7345.1-7345.6. doi:10.1038/srep07345

Author Fang, Weiguo
Lu, Hsiao-Ling
King, Glenn F
St. Leger, Raymond J.
Title Construction of a hypervirulent and specific mycoinsecticide for locust control
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2014-12-05
Sub-type Article (original research)
DOI 10.1038/srep07345
Open Access Status DOI
Volume 4
Start page 7345.1
End page 7345.6
Total pages 6
Place of publication London, United Kingdom
Publisher Nature
Language eng
Formatted abstract
Locusts and grasshoppers (acridids) are among the worst pests of crops and grasslands worldwide. Metarhizium acridum, a fungal pathogen that specifically infects acridids, has been developed as a control agent but its utility is limited by slow kill time and greater expense than chemical insecticides. We found that expression of four insect specific neurotoxins improved the efficacy of M. acridum against acridids by reducing lethal dose, time to kill and food consumption. Coinoculating recombinant strains expressing AaIT1(a sodium channel blocker) and hybrid-toxin (a blocker of both potassium and calcium channels), produced synergistic effects, including an 11.5-fold reduction in LC50, 43% reduction in LT50 and a 78% reduction in food consumption. However, specificity was retained as the recombinant strains did not cause disease in non-acridids. Our results identify a repertoire of toxins with different modes of action that improve the utility of fungi as specific control agents of insects.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 07 Jan 2015, 21:59:51 EST by Susan Allen on behalf of Institute for Molecular Bioscience