Chirality of reduced haloperidol in humans

Eyles, DW, McGrath, JJ, Stedman, TJ and Pond, SM (1998) Chirality of reduced haloperidol in humans. European Neuropsychopharmacology, 8 2: 127-129.

Author Eyles, DW
McGrath, JJ
Stedman, TJ
Pond, SM
Title Chirality of reduced haloperidol in humans
Journal name European Neuropsychopharmacology   Check publisher's open access policy
ISSN 0924-977X
Publication date 1998-01-01
Year available 1998
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 8
Issue 2
Start page 127
End page 129
Total pages 3
Place of publication AMSTERDAM
Language eng
Abstract In vitro, cytosolic human ketone reductases catalyse the stereospecific (i.e. >99%) formation of S(-) reduced haloperidol (RHP) from haloperidol (HP). Whether this situation is reflected in patients taking the drug is unknown. In this study in nine patients taking HP, only 73.2+/-18.2% of the RHP excreted in urine was the S(-) enantiomer. Thus, enzymes other than cytosolic ketone reductases must be responsible for the formation of the minor enantiomer. (C) 1998 Elsevier Science B.V./ECNP.
Keyword Clinical Neurology
Pharmacology & Pharmacy
Reduced Haloperidol
Stereoselective Metabolism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 13 Aug 2007, 20:26:52 EST