Therapeutic opportunities for targeting cold pain pathways

Yin, Kathleen, Zimmermann, Katharina, Vetter, Irina and Lewis, Richard J. (2015) Therapeutic opportunities for targeting cold pain pathways. Biochemical Pharmacology, 93 2: 125-140. doi:10.1016/j.bcp.2014.09.024

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Author Yin, Kathleen
Zimmermann, Katharina
Vetter, Irina
Lewis, Richard J.
Title Therapeutic opportunities for targeting cold pain pathways
Journal name Biochemical Pharmacology   Check publisher's open access policy
ISSN 0006-2952
Publication date 2015-01-15
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.bcp.2014.09.024
Open Access Status Not yet assessed
Volume 93
Issue 2
Start page 125
End page 140
Total pages 16
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 1303 Biochemistry
3004 Pharmacology
Abstract Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities, such as heat pain, the mechanisms behind physiological and pathological cold pain remain elusive. Moreover, it is becoming increasingly evident that cold pain pharmacology differs between various neuropathic pain conditions, making mechanism-directed treatment based on an understanding of the underlying pathophysiological mechanisms imperative to achieving clinical success. Here we review the processes of physiological and abnormal cold sensing, the pharmacology of cold nociception, cold hyperalgesia and cold allodynia, and provide an overview of cold pain syndromes and their current and potential treatments.
Keyword Cold pain signalling
Ion channels
TRP channels
Pain pathways
Cold pain sensitisation
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID ZI 1172/3-1
Institutional Status UQ
Additional Notes Available online: 12 October 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Tue, 06 Jan 2015, 00:43:11 EST by Susan Allen on behalf of Institute for Molecular Bioscience