The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity

Henstridge, Darren C., Forbes, Josephine M., Penfold, Sally A., Formosa, Melissa F., Dougherty, Sonia, Gasser, Anna, de Courten, Maximilian P., Cooper, Mark E., Kingwell, Bronwyn A. and de Courten, Barbora (2010) The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity. Metabolism: Clinical and Experimental, 59 11: 1556-1561. doi:10.1016/j.metabol.2010.01.027


Author Henstridge, Darren C.
Forbes, Josephine M.
Penfold, Sally A.
Formosa, Melissa F.
Dougherty, Sonia
Gasser, Anna
de Courten, Maximilian P.
Cooper, Mark E.
Kingwell, Bronwyn A.
de Courten, Barbora
Title The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity
Journal name Metabolism: Clinical and Experimental   Check publisher's open access policy
ISSN 0026-0495
1532-8600
Publication date 2010-11-01
Sub-type Article (original research)
DOI 10.1016/j.metabol.2010.01.027
Open Access Status Not Open Access
Volume 59
Issue 11
Start page 1556
End page 1561
Total pages 6
Place of publication Maryland Heights, MO United States
Publisher W.B. Saunders
Language eng
Formatted abstract
Decreased gene expression of heat shock protein 72 (HSP72) in skeletal muscle is associated with insulin resistance in humans. We aimed to determine whether HSP72 protein expression in insulin-sensitive tissues is related to criterion standard measures of adiposity and insulin resistance in a young healthy human population free of hyperglycemia. Healthy participants (N = 17; age, 30 ± 3 years) underwent measurement of body composition (dual-energy x-ray absorptiometry), a maximum aerobic capacity test (V̇o2max), an oral glucose tolerance test, and a hyperinsulinemic-euglycemic clamp (M) to access insulin sensitivity. Skeletal muscle and subcutaneous adipose tissue biopsies were obtained by percutaneous needle biopsy. HSP72 protein expression in skeletal muscle was inversely related to percentage body fat (r = −0.54, P < .05) and remained significant after adjustment for age and sex (P < .05). Insulin sensitivity was also related to HSP72 protein expression in skeletal muscle (r = 0.52, P < .05); however, this relationship disappeared after adjustment for percentage body fat (P = .2). In adipose tissue, HSP72 protein expression was not related to adiposity or insulin sensitivity. Physical activity and aerobic fitness did not show any association with HSP72 protein expression in either tissue studied. A lower expression of HSP72 protein in human skeletal muscle was associated with increased adiposity and decreased insulin sensitivity in healthy individuals. These findings are consistent with rodent data suggesting that HSP72 stimulates fat oxidation with consequent reduction in fat storage and adiposity.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
 
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