Number of osteoporotic sites as a modifying factor for bone mineral density

Lee, Jong Seok, Lee, Sungwha, Ryu, Ohk-Hyun, Choi, Moon-Gi and Kim, Youn Ji (2014) Number of osteoporotic sites as a modifying factor for bone mineral density. Journal of Bone and Mineral Metabolism, 33 6: 684-693. doi:10.1007/s00774-014-0635-1

Author Lee, Jong Seok
Lee, Sungwha
Ryu, Ohk-Hyun
Choi, Moon-Gi
Kim, Youn Ji
Title Number of osteoporotic sites as a modifying factor for bone mineral density
Journal name Journal of Bone and Mineral Metabolism   Check publisher's open access policy
ISSN 1435-5604
Publication date 2014-12-19
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s00774-014-0635-1
Volume 33
Issue 6
Start page 684
End page 693
Total pages 10
Place of publication Tokyo, Japan
Publisher Springer Japan
Language eng
Abstract Discordance has been proposed as a new predictor of fracture risk that may affect fracture risk via bone mineral density (BMD). With an emphasis on better understanding the relationship between discordance and BMD, the aim of this study was to determine the effect of the number of osteoporotic sites, as an indicator of discordance, on BMD and to explore the clinical significance of BMD modification by this factor. This study was based on data obtained from the Korea National Health and Nutrition Examination Survey 2008–2011, which is a nationwide cross-sectional study. Among postmenopausal women aged 50 years or older, 3,849 women whose BMD was measured at three sites (lumbar spine, femoral neck, and total hip) were included in the study. The diagnosis was consistent across sites in only 39.2–59.0 % of cases. Lumbar spine T-score was reduced by 0.163 for two osteoporotic sites and by 0.462 for three osteoporotic sites, compared with having one osteoporotic site at the lumbar spine only. Femoral neck T-score was reduced by 0.609 for three osteoporotic sites compared with one or two osteoporotic sites. Using BMD adjusted for discordance, we found fracture risk probability changed significantly. Our results confirmed that BMD discordance was considerably high among Korean women in their 50s and older owing to site-dependent differences in the pattern of BMD reduction with age. Mean BMD decreased with increasing number of osteoporotic sites. Using a modified BMD adjusted for the number of osteoporotic sites may offer more accurate fracture risk assessment.
Keyword Bone mineral density
Fracture risk assessment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 19 Dec 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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