Extreme hypertriglyceridemia managed with insulin

Thuzar, Moe, Shenoy, Vasant V., Malabu, Usman H., Schrale, Ryan and Sangla, Kunwarjit S. (2014) Extreme hypertriglyceridemia managed with insulin. Journal of Clinical Lipidology, 8 6: 630-634. doi:10.1016/j.jacl.2014.09.004

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Author Thuzar, Moe
Shenoy, Vasant V.
Malabu, Usman H.
Schrale, Ryan
Sangla, Kunwarjit S.
Title Extreme hypertriglyceridemia managed with insulin
Journal name Journal of Clinical Lipidology
ISSN 1933-2874
Publication date 2014-12-01
Sub-type Article (original research)
DOI 10.1016/j.jacl.2014.09.004
Open Access Status Not yet assessed
Volume 8
Issue 6
Start page 630
End page 634
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 2724 Internal Medicine
2712 Endocrinology, Diabetes and Metabolism
2916 Nutrition and Dietetics
2705 Cardiology and Cardiovascular Medicine
Abstract Extreme hypertriglyceridemia can lead to acute pancreatitis and rapid lowering of serum triglycerides (TG) is necessary for preventing such life-threatening complications. However, there is no established consensus on the acute management of extreme hypertriglyceridemia. We retrospectively reviewed 10 cases of extreme hypertriglyceridemia with mean serum TG on presentation of 101.5 ± 23.4 mmol/L (8982 ± 2070 mg/dL) managed with insulin. Serum TG decreased by 87 ± 4% in 24 hours in those patients managed with intravenous insulin and fasting and 40 ± 8.4% in those managed with intravenous insulin alone (P = .0003). The clinical course was uncomplicated in all except 1 patient who subsequently developed a pancreatic pseudocyst. Thus, combination of intravenous insulin with fasting appears to be an effective, simple, and safe treatment strategy in immediate management of extreme hypertriglyceridemia.
Keyword Hypertriglyceridemia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 29 Dec 2014, 21:46:32 EST by Moe Thuzar on behalf of Medicine - Royal Brisbane and Women's Hospital