Vitamin D and the brain: key questions for future research

Cui, Xiaoying, Gooch, Helen, Groves, Natalie J., Sah, Pankaj, Burne, Thomas H., Eyles, Darryl W. and McGrath, John J. (2015) Vitamin D and the brain: key questions for future research. The Journal of Steroid Biochemistry and Molecular Biology, 148 305-309. doi:10.1016/j.jsbmb.2014.11.004

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Author Cui, Xiaoying
Gooch, Helen
Groves, Natalie J.
Sah, Pankaj
Burne, Thomas H.
Eyles, Darryl W.
McGrath, John J.
Title Vitamin D and the brain: key questions for future research
Journal name The Journal of Steroid Biochemistry and Molecular Biology   Check publisher's open access policy
ISSN 1879-1220
Publication date 2015-04-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jsbmb.2014.11.004
Open Access Status File (Author Post-print)
Volume 148
Start page 305
End page 309
Total pages 5
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 2712 Endocrinology, Diabetes and Metabolism
2700 Medicine
1303 Biochemistry
1313 Molecular Medicine
1312 Molecular Biology
1310 Endocrinology
1308 Clinical Biochemistry
1307 Cell Biology
Abstract Over the last decade a convergent body of evidence has emerged from epidemiology, animal experiments and clinical trials which links low vitamin D status with a range of adverse neuropsychiatric outcomes. This research demonstrates that the timing of exposure to low vitamin D influences the nature of brain phenotypes, as exposures during gestation versus adulthood result in different phenotypes. With respect to early life exposures, there is robust evidence from rodent experiments indicating that transient developmental vitamin D (DVD) deficiency is associated with changes in brain structure, neurochemistry, gene and protein expression and behavior. In particular, DVD deficiency is associated with alterations in the dopaminergic neurotransmitter systems. In contrast, recently published animal experiments indicate that adult vitamin D (AVD) deficiency is associated with more subtle neurochemical and behavioral phenotypes. This paper explores key issues that need to be addressed in future research. There is a need to define the timing and duration of the ‘critical window’ during which low vitamin D status is associated with differential and adverse brain outcomes. We discuss the role for ‘two-hit hypotheses’, which propose that adult vitamin D deficiency leaves the brain more vulnerable to secondary adverse exposures, and thus may exacerbate disease progression. Finally, we explore the evidence implicating a role for vitamin D in rapid, non-genomic mechanisms that may involve L-type calcium channels and brain function
Keyword Hydroxyvitamin D
Calcium channels
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID APP1007677
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 28 times in Scopus Article | Citations
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Created: Wed, 17 Dec 2014, 02:39:15 EST by Susan Day on behalf of Queensland Brain Institute